Robbins Pathologic Basis of Disease

Differently substituted flavanones were isolated from Leguminosae and their antibacterial activity was comparatively studied against methicillin-resistant Staphylococcus aureus (MRSA). The minimum inhibitory concentrations (MICs) of phytochemical flavanones to clinical isolates of MRSA were determined by a serial agar dilution method. The structure-activity relationship has indicated that 2',4'- or 2',6'-dihydroxylation of the B ring and 5,7-dihydroxylation of the A ring in the flavanone structure are important for significant anti-MRSA activity and that substitution with a certain aliphatic group at the 6- or 8-position also enhances the activity. Among the thirteen flavanones tested, tetrahydroxyflavanones with these structural characteristics isolated from Sophora exigua and Echinosophora koreensis showed intensive activity to inhibit the growth of all MRSA strains at 3.13-6.25 micrograms/ml. The present hydroxyflavanones would be useful in the phytotherapeutic strategy against MRSA infections.

Comparative Study on the Antibacterial Activity of Phytochemical Flavanones against Methicillin-resistant Staphylococcus aureus.

Herbal medicines have long been used as a traditional mode of therapy for various ailments in India. They are being used increasingly as dietary supplements to ward off common diseases. Periodontal diseases are highly prevalent and can affect up to 90% of the world population. Gingivitis is the mild form whereas periodontitis results in an irreversible loss of supporting structures of the teeth. Even though periodontal pathogens form a crucial component in the etiopathogenesis of periodontitis, there is a growing body of evidence suggesting oxidative stress playing a pivotal role in the disease initiation and progression. Studies have shown a direct correlation between increased levels of biomarkers for tissue damage induced by reactive oxygen species (ROS) to the severity of periodontal disease. Thus, the focus of attention has revolved back to herbal medicines due to their wide spectrum of biological and medicinal activities, lower costs, and higher safety margin. Internet databases Pubmed and Google Scholar were searched, and the most relevant articles were considered for review. This review briefly describes the various herbs with antioxidant capacity and their potency in the treating periodontal disease.

Herbs as an antioxidant arsenal for periodontal diseases.

Perspective on the application of medicinal plants and natural products in wound healing: A mechanistic review.

Ethnomedicinal plants used to treat skin diseases by Tharu community of district Udham Singh Nagar, Uttarakhand, India

Objective
To establish the wound healing activity of aqueous and ethanolic extract of roots of Ficus racemosa (F. racemosa).

Enhancement of wound healing with roots of Ficus racemosa L. in albino rats

Problems statement: To evaluate the antimicrobial activity of aqueous and ethanolic extracts of Ficus benghalensis and Ficus racemosa against three bacterial strains that is Staphylococcus aureus, Pseudomonas aeruginosa and Klebsiella pneumonia. Approach: The different concentrations viz. 25, 50 and 75 mg mL-1 of aqueous as well as ethanolic extract solutions of roots of Ficus benghalensis and Ficus racemosa were tested against above three bacterial strains. The effects were compared with that of a standard antibiotic-loaded disc, ampicillin (10 mcg/disc) of Himedia Labs. Finally, the plates were incubated with lids closed at 37°C for 24 h. Discs were observed for zones of inhibition by measuring the Diameter of Inhibition Zone (DIZ) using a ruler. Results: Ficus racemosa ethanolic extract showed maximum inhibition against Staphylococcus aureus when compared with Ficus benghalensis ethanolic extract. However standard drug ampicillin showed maximum antimicrobial activity compared with both the plants. Conclusion: In conclusion, it was clearly observed that ethanolic extract of both the plants were having good antimicrobial activity towards Staphylococcus aureus.

/pdf/antimicrobial-activity-of-ficus-benghalensis-and-ficus-1emimckfam.pdf

Antimicrobial Activity of Ficus benghalensis and Ficus racemosa roots L.

https://cyberleninka.org/article/n/171238.pdf

Healing promoting potentials of roots of Ficus benghalensis L. in albino rats.

/pdf/exploration-of-preliminary-phytochemical-studies-of-roots-of-1fpcik53y0.pdf

Exploration of preliminary phytochemical studies of roots of ficus racemosa

Problem statement: Ficus benghalensis is widely used plant world wide traditionally as well as scientifically. It has a wide uses in various medical ailments. As a part of pharmacological evaluations, we have carried out wound healing activity specially in dexamethasone depressed healing conditions. Approach: Wound healing activity was established by two medels namely incision and excision. Results: The roots of Ficus benghalensis clearly reverted the antihealing in presence of dexamethasone treated animals. It happened through increase in breaking strength in incision model and increase in percentage wound contraction and reduction in period of epithelialization. Conclusion: Presence of various chemical constituents in the roots of Ficus benghalensis specially saponins, flavanoids, taannins and alkaloids were responsible for antagonizing the antihealing effect of dexamethasone treated animals.

Reversal of Dexamethasone Depressant Action in Wound Healing by Ficus Benghalensis L. Roots

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