Underhill Da
University of Western Ontario
7 Papers
39 Citations
Underhill Da is an academic researcher from University of Western Ontario. The author has contributed to research in topics: Peptide sequence & Gene. The author has an hindex of 7, co-authored 7 publications.
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Papers
Cis-regulatory elements within the proximal promoter of the rat gene encoding corticosteroid-binding globulin
Underhill Da,Geoffrey L. Hammond +1 more
TL;DR: Electrophoretic mobility-shift assays indicted that the P1 element most likely binds HNF-1, and transient transfection assays with luciferase reporter plasmids demonstrated that P1-P5 represent a positive component of rat pCbg activity.
25
Corticosteroid binding globulin, testosterone-estradiol binding globulin, and androgen binding protein belong to protein families distinct from steroid receptors
C.W. Bardin,Glen L. Gunsalus,Neal A. Musto,C Y Cheng,J Reventos,Carolyn L. Smith,Underhill Da,Geoffrey L. Hammond +7 more
TL;DR: The cDNA nucleotide sequences and the deduced amino acid sequences of human corticosteroid binding globulin, human testosterone-estradiol binding Globulin, and rat androgen binding protein were determined and it is concluded that the "extracellular steroid binding proteins and steroid receptors do not appear to have descended from a common ancestor".
15
Molecular studies of corticosteroid binding globulin structure, biosynthesis and function.
TL;DR: It is suggested that a specific interaction between CBG and elastase on the surface of neutrophils may represent a physiologically important event that promotes the delivery of glucocorticoids to these cells at sites of inflammation.
Organization of the human corticosteroid binding globulin gene and analysis of its 5'-flanking region
Underhill Da,Geoffrey L. Hammond +1 more
TL;DR: The structure of the human corticosteroid binding globulin (CBG) gene has been determined, and restriction endonuclease maps of human placental DNA and cloned genomic DNA indicate that CBG is encoded by a single gene.
The human sex hormone-binding globulin gene contains exons for androgen-binding protein and two other testicular messenger RNAs.
TL;DR: Southern blots of human placental DNA and cloned genomic DNA fragments indicate that sex hormone-binding globulin (SHBG) and its related testicular cDNAs are the products of a single gene.