Uma Santhanam
Rockefeller University
19 Papers
417 Citations
Uma Santhanam is an academic researcher from Rockefeller University. The author has contributed to research in topics: Interleukin 6 & Cytokine. The author has an hindex of 15, co-authored 17 publications.
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Papers
Cytokines in normal and abnormal parturition: elevated amniotic fluid interleukin-6 levels in women with premature rupture of membranes associated with intrauterine infection.
Uma Santhanam,Cecilia Avila,Roberto Romero,Huguette Viguet,Nobuo Ida,Shingou Sakurai,Pravinkumar B. Sehgal +6 more
TL;DR: The participation of interleukin-6 in the pathophysiology of normal and abnormal human parturition was evaluated by determining IL-6 concentrations in amniotic fluid using the B9 hybridoma growth factor assay and a monoclonal antibody-based ELISA.
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Regulation of the acute phase and immune responses in viral disease. Enhanced expression of the beta 2-interferon/hepatocyte-stimulating factor/interleukin 6 gene in virus-infected human fibroblasts.
Pravinkumar B. Sehgal,D. C. Helfgott,Uma Santhanam,Stephen B. Tatter,R H Clarick,J. Ghrayeb,Lester T. May +6 more
TL;DR: In this paper, the expression of the mRNA for, and secretion of, IFN-beta 2/hepatocyte-stimulating factor/IL-6 in human diploid fibroblasts (FS-4 strain) infected with different RNA-and DNA-containing viruses was defined.
•Journal Article
IL-6/IFN-beta 2 in synovial effusions of patients with rheumatoid arthritis and other arthritides. Identification of several isoforms and studies of cellular sources.
Nina Bhardwaj,Uma Santhanam,Lisa L. Lau,Stephen B. Tatter,J. Ghrayeb,M. Rivelis,Ralph M. Steinman,Pravinkumar B. Sehgal,Lester T. May +8 more
TL;DR: Findings suggest that IL-6 is involved in inflammatory joint disease, however, the primary cells synthesizing it may be located in the synovial lining instead of the joint exudate.
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Regulation of Expression of Interleukin‐6
Anuradha Ray,Stephen B. Tatter,Uma Santhanam,D. C. Helfgott,Lester T. May,Pravinkumar B. Sehgal +5 more
TL;DR: The regulation of expression of the IL-6 gene appears to be particularly adapted to the key function of this cytokine, namely, that of an alarm signal which recruits diverse nonspecific and specific host defense mechanisms in an attempt to limit tissue damage.
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The relationship of serum IL-6 levels to acute graft-versus-host disease and hepatorenal disease after human bone marrow transplantation.
Frank W. Symington,Banu E. Symington,P. Y. Liu,Huguette Viguet,Uma Santhanam,Pravinkumar B. Sehgal +5 more
TL;DR: The idea that acute GVHD in humans involves a cytokine cascade that includes production of IL-6 in addition to the previously reported involvement of tumor necrosis factor alpha and interferon-gamma is supported.
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