Uma M Sharma
East Carolina University
6 Papers
2 Citations
Uma M Sharma is an academic researcher from East Carolina University. The author has contributed to research in topics: Apoptosis & Cardioprotection. The author has an hindex of 2, co-authored 4 publications.
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Papers
Intrinsic adaptations in OXPHOS power output and reduced tumorigenicity characterize doxorubicin resistant ovarian cancer cells.
James T Hagen,McLane M. Montgomery,Ericka Biagioni,Polina M. Krassovskaia,Filip Jevtovic,Daniel Shookster,Uma M Sharma,Kang Tung,Nick Broskey,Linda May,Hui Huang,Jeffrey J. Brault,P. Darrell Neufer,Myles C. Cabot,Kelsey H. Fisher-Wellman +14 more
TL;DR: In this paper , the authors investigated the impact of ABCB1 activity on mitochondrial respiratory kinetics and found that increased mitochondrial content and enhanced respiratory complex I (CI) boosted intrinsic oxidative phosphorylation (OXPHOS) power output.
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Tideglusib Ameliorates Ischemia/Reperfusion Damage by Inhibiting GSK-3β and Apoptosis in Rat Model of Ischemic Stroke.
TL;DR: Tideglusib pre-treatment but not post-treatment significantly improved neurobehavioral parameters (p < 0.05) and reduced brain damage as mentioned in this paper , when compared with MCAo group.
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Abstract 590: EphrinA1-Fc Attenuates Dysfunction and Fibrosis in Nonreperfused Myocardium at 4 weeks Post-MI in WT B6 but Not EphA2-R Mutant Mice
TL;DR: The potential of a single administration of ephrinA1-Fc to not only attenuate acute ischemic injury but also mitigate pathological accumulation of interstitial fibrosis and remodeling, thereby reducing ventricular stiffening and the resultant progression to heart failure is demonstrated.
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Intracardiac administration of ephrinA1-Fc preserves mitochondrial bioenergetics during acute ischemia/reperfusion injury
Maria J. Torres,Kelsey L. McLaughlin,Randall H. Renegar,Smrithi Valsaraj,K'Shylah S Whitehurst,Omar M. Sharaf,Uma M Sharma,Julie L. Horton,Brinda Sarathy,Justin Parks,Jeffrey J. Brault,Kelsey H. Fisher-Wellman,P. Darrell Neufer,Jitka A. I. Virag +13 more
TL;DR: It is suggested that intracardiac injection of EphrinA1-Fc protects cardiac function by preserving cardiomyocyte structure and mitochondrial bioenergetics, thus emerging as a potential therapeutic strategy in I/R injury.
EphrinA1-Fc attenuates myocardial ischemia/reperfusion injury in mice
Augustin DuSablon,Justin Parks,K'Shylah S Whitehurst,Heather K Estes,Robert C Chase,Eleftherios Vlahos,Uma M Sharma,David W Wert,Jitka A. I. Virag +8 more
TL;DR: Reduced injury is due to a combination of adaptive metabolic reprogramming, improved cell survival, and decreased inflammatory cell recruitment, suggesting that ephrinA1-Fc enhances the capacity of the heart to withstand an ischemic insult.