Ulrike Boenisch
Max Planck Society
7 Papers
3 Citations
Ulrike Boenisch is an academic researcher from Max Planck Society. The author has contributed to research in topics: Epigenome & PRC2. The author has an hindex of 3, co-authored 7 publications.
Chat about Author
Papers
Paternal Diet Defines Offspring Chromatin State and Intergenerational Obesity
Anita Öst,Anita Öst,Adelheid Lempradl,Eduard Casas,Melanie Weigert,Theodor Tiko,Merdin Deniz,Lorena Pantano,Ulrike Boenisch,Pavel M. Itskov,Marlon Stoeckius,Marius Ruf,Nikolaus Rajewsky,Gunter Reuter,Nicola Iovino,Carlos Ribeiro,Mattias Alenius,Steffen Heyne,Tanya Vavouri,J. Andrew Pospisilik +19 more
TL;DR: A Drosophila model of paternal-diet-induced intergenerational metabolic reprogramming (IGMR) is presented and evidence that a similar system may regulate obesity susceptibility and phenotype variation in mice and humans is found.
415
The Polycomb-Dependent Epigenome Controls β Cell Dysfunction, Dedifferentiation, and Diabetes.
Tess Tsai Hsiu Lu,Steffen Heyne,Erez Dror,Eduard Casas,Laura Leonhardt,Laura Leonhardt,Thorina Boenke,Chih-Hsiang Yang,Sagar,Laura Arrigoni,Kevin Dalgaard,Raffaele Teperino,Lennart Enders,Madhan Selvaraj,Marius Ruf,Sunil Jayaramaiah Raja,Huafeng Xie,Ulrike Boenisch,Stuart H. Orkin,Francis C. Lynn,Brad G. Hoffman,Dominic Grün,Tanya Vavouri,Adelheid Lempradl,J. Andrew Pospisilik +24 more
TL;DR: Deep epigenome mapping with single-cell transcriptomics finds two chromatin-state signatures that track β cell dysfunction in mice and humans: ectopic activation of bivalent Polycomb-silenced domains and loss of expression at an epigenomically unique class of lineage-defining genes.
132
Ultra-parallel ChIP-seq by barcoding of intact nuclei
Laura Arrigoni,Al-Hasani H,Fidel Ramírez,Ilaria Panzeri,Devon Ryan,Diana Santacruz,Nadia Kress,Andrew Pospisilik,Ulrike Boenisch,Thomas Manke +9 more
TL;DR: A novel method for ultra-parallelized high-throughput ChIP-seq that employs barcoding of chromatin within intact nuclei extracted from different sources, for maximal comparability and significant workload reduction.
The Polycomb-dependent epigenome controls β-cell dysfunction, dedifferentiation and diabetes
Tess Tsai Hsiu Lu,Steffen Heyne,Erez Dror,Eduard Casas,Laura Leonhardt,Thorina Boenke,Chih-Hsiang Yang,Sagar,Laura Arrigoni,Kevin Dalgaard,Raffaele Teperino,Lennart Enders,Madhan Selvaraj,Marius Ruf,Sunil Jayaramaiah Raja,Huafeng Xie,Ulrike Boenisch,Stuart H. Orkin,Francis C. Lynn,Brad G. Hoffman,Dominic Grün,Tanya Vavouri,Adelheid Lempradl,J. Andrew Pospisilik +23 more
TL;DR: The data suggest a two-hit model for loss of β-cell identity in diabetes and highlight epigenetic therapeutic potential to block dedifferentiation.
1