Ulrich Stelzl
University of Graz
82 Papers
313 Citations
Ulrich Stelzl is an academic researcher from University of Graz. The author has contributed to research in topics: Biology & Interactome. The author has an hindex of 30, co-authored 75 publications. Previous affiliations of Ulrich Stelzl include Max Delbrück Center for Molecular Medicine & Medical University of Graz.
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Papers
Dynamic Protein-Protein Interaction Wiring of the Human Spliceosome
Anna Hegele,Atanas Kamburov,Arndt Grossmann,Chrysovalantis Sourlis,Sylvia J. Wowro,Mareike Weimann,Cindy L. Will,Vlad Pena,Reinhard Lührmann,Ulrich Stelzl +9 more
TL;DR: Interactions between human spliceosomal proteins suggest that during step 1 of splicing, hPRP8 interactions with SF3b proteins are replaced by hSLU7, positioning this second step factor close to the active site, and that the DEAH-box helicases h PRP2 and hPRp16 cooperate through ordered interactions with GPKOW.
The Molecular Architecture of Native BBSome Obtained by an Integrated Structural Approach.
Hui-Ting Chou,Luise Apelt,Daniel P. Farrell,Susan Roehl White,Jonathan Woodsmith,Vladimir Svetlov,Jaclyn S. Goldstein,Andrew R. Nager,Zixuan Li,Jean Muller,Hélène Dollfus,Evgeny Nudler,Ulrich Stelzl,Frank DiMaio,Maxence V. Nachury,Maxence V. Nachury,Thomas Walz,Thomas Walz +17 more
TL;DR: This model provides the first detailed view of the machinery enabling ciliary exit and finds that BBSome subunits have a very high degree of interconnectivity, explaining the obligate nature of the complex.
The value of high quality protein-protein interaction networks for systems biology.
Ulrich Stelzl,Erich E. Wanker +1 more
TL;DR: Combined PPI networks can become valuable resources for a systems-level understanding of cellular processes and complex phenotypes through integration of interaction data with other qualitative and quantitative information.
Global BioID-based SARS-CoV-2 proteins proximal interactome unveils novel ties between viral polypeptides and host factors involved in multiple COVID19-associated mechanisms
Estelle M.N. Laurent,Yorgos Sofianatos,Anastassia V. Komarova,Jean-Pascal Gimeno,Payman Samavarchi Tehrani,Dae-Kyum Kim,Hala Abdouni,Marie Duhamel,Patricia Cassonnet,Jennifer J. Knapp,Da Kuang,Aditya Chawla,Dayag Sheykhkarimli,Ashyad Rayhan,Roujia Li,Oxana Pogoutse,David E. Hill,Michael A. Calderwood,Pascal Falter-Braun,Patrick Aloy,Ulrich Stelzl,Marc Vidal,Anne-Claude Gingras,Georgios A. Pavlopoulos,Sylvie van der Werf,Isabelle Fournier,Frederick P. Roth,Michel Salzet,Caroline Demeret,Yves Jacob,Etienne Coyaud +30 more
TL;DR: This study provides an unprecedented comprehensive resource for understanding how SARS-CoV-2 proteins orchestrate host proteome remodeling and innate immune response evasion, which can inform development of targeted therapeutic strategies.
Dual Coordination of Post Translational Modifications in Human Protein Networks
TL;DR: Two global PTM coordination mechanisms are revealed and dataset integration is emphasized as requisite in proteomic PTM studies to better predict modification impact on cellular signaling.