Ulla Seibel
University of Regensburg
6 Papers
15 Citations
Ulla Seibel is an academic researcher from University of Regensburg. The author has contributed to research in topics: Histamine receptor & Histamine H3 receptor. The author has an hindex of 4, co-authored 6 publications.
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Papers
A Versatile Sub-Nanomolar Fluorescent Ligand Enables NanoBRET Binding Studies and Single-Molecule Microscopy at the Histamine H 3 Receptor
Niklas Rosier,Lukas Grätz,Hannes Schihada,Jan Möller,Jan Möller,Ali Işbilir,Ali Işbilir,Laura J Humphrys,Martin Nagl,Ulla Seibel,Martin J. Lohse,Martin J. Lohse,Steffen Pockes,Steffen Pockes +13 more
TL;DR: In this paper, a novel fluorescent H3R ligand called UR-NR266 was synthesized, which showed fast association to its target and complete dissociation in kinetic binding studies.
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A Dynamic, Split-Luciferase-Based Mini-G Protein Sensor to Functionally Characterize Ligands at All Four Histamine Receptor Subtypes.
Carina Höring,Ulla Seibel,Katharina Tropmann,Lukas Grätz,Denise Mönnich,Sebastian Pitzl,Günther Bernhardt,Steffen Pockes,Andrea Strasser +8 more
TL;DR: The split-NanoLuc method was applied to the four histamine receptor subtypes and recently engineered minimal G (mini-G) proteins and a significant positive correlation of the signal amplitude and the mini-G protein expression level was demonstrated in the case of the H2R, but not for the H1R or the H3R.
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Alkyl derivatives of 1,3,5-triazine as histamine H4 receptor ligands
Dorota Łażewska,Szczepan Mogilski,Stefanie Hagenow,Kamil Kuder,Monika Głuch-Lutwin,Agata Siwek,Małgorzata Więcek,Maria Kaleta,Ulla Seibel,Armin Buschauer,Barbara Filipek,Holger Stark,Katarzyna Kieć-Kononowicz +12 more
TL;DR: This study focuses on the design, synthesis, molecular modeling and biological evaluation of a novel group of alkyl-1,3,5-triazinyl-methylpiperazines, which exhibited hH4R affinity with a Ki of 160 nM and behaved as antagonist in functional assays.
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UR-DEBa242: A Py-5-Labeled Fluorescent Multipurpose Probe for Investigations on the Histamine H3 and H4 Receptors
Edith Bartole,Lukas Grätz,Timo Littmann,David Wifling,Ulla Seibel,Armin Buschauer,Günther Bernhardt +6 more
TL;DR: Twenty-six Py-5-labeled histamine derivatives were synthesized and biologically characterized and proved suitable for hH4R localization and trafficking studies in live cells, and 26 as a useful molecular tool to determine hH3,4Rs/mH 4R binding affinities of ligands binding to these receptors.