Ulla Holtbäck
Karolinska Institutet
23 Papers
281 Citations
Ulla Holtbäck is an academic researcher from Karolinska Institutet. The author has contributed to research in topics: Kidney & Dopamine. The author has an hindex of 15, co-authored 23 publications. Previous affiliations of Ulla Holtbäck include Science for Life Laboratory & Uppsala University.
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Papers
Negative reciprocity between angiotensin II type 1 and dopamine D1 receptors in rat renal proximal tubule cells.
TL;DR: Results indicate that AT1R and D1R function as a unit of opposites, which should provide a highly versatile and sensitive system for short-term regulation of sodium excretion.
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Molecular determinants of sodium and water balance during early human development.
Ulla Holtbäck,Anita Aperia +1 more
TL;DR: It is proposed that further studies on how these transporters are regulated will lead to the improved prevention and treatment of salt water balance disorders in infants.
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Prevention of apoptosis averts glomerular tubular disconnection and podocyte loss in proteinuric kidney disease
Ievgeniia Burlaka,Linnéa Nilsson,Lena Scott,Ulla Holtbäck,Ann-Christine Eklöf,Agnes B. Fogo,Hjalmar Brismar,Hjalmar Brismar,Anita Aperia +8 more
TL;DR: Ouabain is identified a novel clinically feasible therapeutic tool, which has the potential to protect from apoptosis and rescue from loss of functional tissue in chronic proteinuric kidney disease.
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Prolactin, a natriuretic hormone, interacting with the renal dopamine system.
Fernando Ibarra,Susanne Crambert,Susanne Crambert,Ann-Christine Eklöf,Ann-Christine Eklöf,Annika Lundquist,Annika Lundquist,Peter Hansell,Peter Hansell,Ulla Holtbäck,Ulla Holtbäck +10 more
TL;DR: It is concluded that prolactin is a natriuretic hormone which interacts with the renal dopamine system for its effects and the natriurestic response is associated with inhibition of proximal tubular Na(+), K(+)-ATPase activity.
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Cellular mechanisms for bi-directional regulation of tubular sodium reabsorption.
Anita Aperia,Jessica Fryckstedt,Ulla Holtbäck,Roger Belusa,Xian-Jun Cheng,Ann-Christine Eklöf,Dailin Li,Zhang-Ming Wang,Yoshiyuki Ohtomo +8 more
TL;DR: A general model for a bi-directional control of tubular sodium transporters by natriuretic and antinatrioretic factors is proposed based on experimental data from studies on the regulation of the activity of Na+,K+-ATPase, the enzyme that provides the electrochemical gradient necessary for tubular reabsorption of electrolytes and solutes in all tubular segments.
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