Data on the synthesis, chemical properties and applications of naphthyridines published mainly over the last 15 years are described systematically and analysed. The bibliography includes 238 references.

https://iopscience.iop.org/article/10.1070/RC2000v069n03ABEH000553/pdf

Naphthyridines. Structure, physicochemical properties and general methods of synthesis

Publisher Summary This chapter reviews the analysis made of the synthesis and properties of six isomeric heterocyclic systems containing two fused pyridine rings with different mutual arrangements of nitrogen atoms; naphthyridines. The interest in naphthyridine derivatives is due to its practical importance. They have an exceptionally broad spectrum of biological activities, and are used for the diagnosis and treatment of different human diseases; agriculture, animal husbandry for external- and internal-parasite control, in industry as preservatives and components of lubricating coolants for metal processing, and in analytical chemistry as ligands. The analysis of the data on the synthesis, chemical properties, and biological activities of the six isomeric pyridopyridines published over the last 20 years is indicative of a lively interest in different aspects of their chemistry. This interest is generally associated with the practical utility of their derivatives possessing a very broad spectrum of the biological activities.

Advances in the Chemistry of Naphthyridines

Transformations of tetrahydrobenzo[b][1,6]naphthyridines and tetrahydropyrido[4,3-b]pyrimidines under the action of dimethyl acetylene dicarboxylate

In this article, we present a convenient and green method for synthesis of β-amino carbonyl compounds through ball-milling technique by using aqueous formic acid, which is an inexpensive and highly efficient catalyst. This multi-component reaction was done at room temperature with high anti-selectivity and easy workup. The use of solvent-free ball-milling technique helped to have high yields and more cleanness, besides omitting the need for solvent in this method.

Aqueous formic acid: an efficient, inexpensive and environmentally friendly catalyst for diastereoselective synthesis of β-amino carbonyl derivatives

Utilisation of 1,3‐Dicarbonyl Derivatives in Multicomponent Reactions

Formation of a 1,6-Naphthyridine Derivative by a Double Mannich Reaction.

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Formation of a 1,6-Naphthyridine Derivative by a Double Mannich Reaction.