Tyson V. Sharp
Queen Mary University of London
55 Papers
309 Citations
Tyson V. Sharp is an academic researcher from Queen Mary University of London. The author has contributed to research in topics: Biology & Gene silencing. The author has an hindex of 23, co-authored 53 publications. Previous affiliations of Tyson V. Sharp include University of London & University of Maryland Biotechnology Institute.
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Papers
Characterization of an anti-apoptotic glycoprotein encoded by Kaposi's sarcoma-associated herpesvirus which resembles a spliced variant of human survivin
TL;DR: It is shown that K7 is a glycoprotein, which can inhibit apoptosis and anchor to intracellular membranes where Bcl‐2 resides, and is designated as vIAP (viral inhibitor‐of‐apoptosis protein), which suggests that survivin‐ΔEx3 might function by a similar mechanism to that of K7.
The Vaccinia Virus E3L Gene Product Interacts with both the Regulatory and the Substrate Binding Regions of PKR: Implications for PKR Autoregulation
Tyson V. Sharp,F. Moonan,A. Romashko,Bhavesh Joshi,Glen N. Barber,Rosemary Jagus,Rosemary Jagus +6 more
TL;DR: A novel autoregulatory mechanism for activation of PKR is suggested in which dsRNA binding to the DRBD induces a conformational change that results in release of the amino terminal region from the substrate binding domain, allowing access to eIF2alpha and its subsequent phosphorylation.
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MicroRNA-155 induction via TNF-α and IFN-γ suppresses expression of programmed death ligand-1 (PD-L1) in human primary cells.
TL;DR: Findings in dermal fibroblasts demonstrate that the IFN-γ/TNF-α/miR-155/PD-L1 pathway is not restricted to HDLECs, and reveal miR- 155 as a critical component of an inflammation-induced regulatory loop controlling PD-L 1 expression in primary cells.
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SMG-1 and mTORC1 Act Antagonistically to Regulate Response to Injury and Growth in Planarians
Christina Gonzalez-Estevez,Daniel A. Felix,Matthew D. Smith,Jordi Paps,Simon J. Morley,Victoria James,Tyson V. Sharp,A. Aziz Aboobaker +7 more
TL;DR: Characterisation of both the planarian mTORC1 signalling components and another PIKK family member as key regulators of regeneration and growth will influence future work on regeneration, growth control, and the development of anti-cancer therapies that target mTOR signalling.
LIM domains-containing protein 1 (LIMD1), a tumor suppressor encoded at chromosome 3p21.3, binds pRB and represses E2F-driven transcription
Tyson V. Sharp,Fernando Munoz,Dimitra Bourboulia,Nadege Presneau,Eva Darai,Hsei-Wei Wang,Mark Cannon,D.N. Butcher,Andrew G. Nicholson,George Klein,Stephan Imreh,Chris Boshoff +11 more
TL;DR: The data indicate that LIMD1 is a tumor-suppressor gene, the protein product of which functionally interacts with pRB and the loss of which promotes lung carcinogenesis.
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