Tyler M. Lu
Cornell University
15 Papers
Tyler M. Lu is an academic researcher from Cornell University. The author has contributed to research in topics: Biology & Induced pluripotent stem cell. The author has an hindex of 6, co-authored 10 publications. Previous affiliations of Tyler M. Lu include Rutgers University & Rutgers Biomedical and Health Sciences.
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Papers
Tumour exosomal CEMIP protein promotes cancer cell colonization in brain metastasis
Gonçalo Rodrigues,Gonçalo Rodrigues,Ayuko Hoshino,Ayuko Hoshino,Ayuko Hoshino,Candia M. Kenific,Irina Matei,Loïc Steiner,Loïc Steiner,Daniela Freitas,Han Sang Kim,Han Sang Kim,Peter R. Oxley,Ilana Scandariato,Irene Casanova-Salas,Jinxiang Dai,Chaitanya R. Badwe,Brunilde Gril,Milica Tesic Mark,Brian D. Dill,Henrik Molina,Haiying Zhang,Alberto Benito-Martin,Linda Bojmar,Yonathan Ararso,Katharine Offer,Quincey LaPlant,Weston Buehring,Huajuan Wang,Xinran Jiang,Tyler M. Lu,Yuan Liu,Joshua K. Sabari,Sandra J. Shin,Navneet Narula,Paula S. Ginter,Vinagolu K. Rajasekhar,John H. Healey,Etienne Meylan,Bruno Costa-Silva,Shizhen Emily Wang,Shahin Rafii,Nasser K. Altorki,Charles M. Rudin,David R. Jones,Patricia S. Steeg,Héctor Peinado,Cyrus M. Ghajar,Jacqueline Bromberg,Jacqueline Bromberg,Maria de Sousa,Maria de Sousa,David J. Pisapia,David Lyden +53 more
TL;DR: It is demonstrated that pre-conditioning the brain microenvironment with exosomes from brain metastatic cells enhances cancer cell outgrowth, and that targeting exosomal CEMIP could constitute a future avenue for the prevention and treatment of brain metastasis.
Pluripotent stem cell-derived epithelium misidentified as brain microvascular endothelium requires ETS factors to acquire vascular fate.
Tyler M. Lu,Sean Houghton,Tarig Magdeldin,José Gabriel Barcia Durán,Andrew P. Minotti,Andrew P. Minotti,Amanda M. Snead,Andrew Sproul,Duc-Huy T. Nguyen,Jenny Xiang,Howard A. Fine,Zev Rosenwaks,Lorenz Studer,Shahin Rafii,Dritan Agalliu,David Redmond,Raphael Lis +16 more
TL;DR: In this paper, a comprehensive transcriptomic metaanalysis of previously published human pluripotent stem cells (hPSC)-derived cells validated by physiological assays was performed. And the authors demonstrated that iBMECs lack functional attributes of ECs since they are deficient in vascular lineage genes while expressing clusters of genes related to the neuroectodermal epithelial lineage.
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Molecular determinants of nephron vascular specialization in the kidney.
David M. Barry,Elizabeth A. McMillan,Balvir Kunar,Raphael Lis,Tuo Zhang,Tyler M. Lu,Edward Daniel,Masataka Yokoyama,Jesus M. Gomez-Salinero,Angara Sureshbabu,Ondine Cleaver,Annarita Di Lorenzo,Mary E. Choi,Jenny Xiang,David Redmond,Sina Y. Rabbany,Sina Y. Rabbany,Thangamani Muthukumar,Shahin Rafii +18 more
TL;DR: This work employs high-throughput bulk and single-cell RNA sequencing of the non-lymphatic endothelial cells of the kidney to identify the molecular pathways that dictate vascular zonation from embryos to adulthood.
Human Induced Pluripotent Stem Cell-Derived Brain Endothelial Cells: Current Controversies.
TL;DR: In this paper, the authors highlight the developments made in the field of human pluripotent stem cells derived brain endothelial cells as well as where experimental data are lacking, and what concerns have emerged since their initial description.
Biomechanical characterization of a novel collagen-hyaluronan infused 3D-printed polymeric device for partial meniscus replacement.
Salim A. Ghodbane,Salim A. Ghodbane,Jay M. Patel,Jay M. Patel,Andrzej Brzezinski,Tyler M. Lu,Charles J. Gatt,Charles J. Gatt,Michael G. Dunn,Michael G. Dunn +9 more
TL;DR: This is the first meniscal scaffold to match both the axial compressive properties and the circumferential tensile stiffness of the native meniscus, and motivates further investigation using a large animal model.
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