Tyler A. Davis
Merck & Co.
19 Papers
29 Citations
Tyler A. Davis is an academic researcher from Merck & Co.. The author has contributed to research in topics: Enantioselective synthesis & Catalysis. The author has an hindex of 9, co-authored 19 publications. Previous affiliations of Tyler A. Davis include Vanderbilt University & Colorado State University.
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Papers
Bifunctional asymmetric catalysis: amplification of Brønsted basicity can orthogonally increase the reactivity of a chiral Brønsted acid.
TL;DR: This new design element leads to a substantially more reactive catalyst for the aza-Henry reaction, one that can promote the addition of a secondary nitroalkane and can be optimized to levels generally greater than 15:1 while the enantioselection remains unchanged at generally >90% ee.
Chiral proton catalysis of secondary nitroalkane additions to azomethine: synthesis of a potent GlyT1 inhibitor.
TL;DR: The first enantioselective synthesis of a potent GlyT1 inhibitor is described, using a 3-nitroazetidine donor used in an enantiOSElective aza-Henry reaction catalyzed by a bis(amidine)-triflic acid salt organocatalyst.
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Rhodium(III)-Catalyzed C-H Activation: An Oxidative Intramolecular Heck-Type Reaction Directed by a Carboxylic Acid.
TL;DR: A wide variety of complex dihydrobenzofurans, dihydRObenzopyrans, and other bicycles that can be easily further functionalized are now accessible through relatively mild reaction conditions.
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Geometric restraint drives on- and off-pathway catalysis by the Escherichia coli menaquinol:fumarate reductase.
Thomas M. Tomasiak,Tara L. Archuleta,Juni Andréll,César Luna-Chavez,Tyler A. Davis,Maruf Sarwar,Amy J. Ham,W. Hayes McDonald,Victoria Yankovskaya,Harry A. Stern,Jeffrey N. Johnston,Elena Maklashina,Elena Maklashina,Gary Cecchini,Gary Cecchini,Tina M. Iverson,Tina M. Iverson +16 more
TL;DR: Crystal structures of Escherichia coli menaquinol:fumarate reductase (QFR), a complex II superfamily member, were determined bound to the substrate, fumarate, and the inhibitors oxaloacetate, glutamate, and 3-nitropropionate, supporting a model where electronic interactions via geometric constraint and orbital steering underlie catalysis by QFR.
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