Twaritha Vijay
6 Papers
Twaritha Vijay is an academic researcher. The author has contributed to research in topics: Gene & Medicine. The author has an hindex of 2, co-authored 3 publications.
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Papers
Diverse partial reprogramming strategies restore youthful gene expression and transiently suppress cell identity.
Antoine E. Roux,Chunlian Zhang,Jonathan S. Paw,Jose Zavala-Solorio,Evangelia Malahias,Twaritha Vijay,Ganesh Kolumam,Cynthia Kenyon,Jacob C. Kimmel +8 more
TL;DR: This paper used single-cell genomics to map the identity trajectory induced by partial reprogramming in multiple murine cell types and dissected the influence of each factor by screening all Yamanaka Factor subsets with pooled singlecell screens.
One Year Follow-up on the First Patient Treated with Nula-Cel: An Autologous CRISPR/Cas9 Gene Corrected CD34+ Cell Product to Treat Sickle Cell Disease
David C. Shyr,Robert Lowsky,Weston Miller,Mark A. Schroeder,Tonia Buchholz,Kirstin Dougall,Allison Intondi,Alexandra Charles,Josh Lehrer,Ali Bouge,Stacey Wolf,Blair MacDonald,Hena Din,Alana Lerner,Manal Amoury,Sebastien Treusch,Glen M. Chew,Brian Silva,Haider Mashhedi,Vincent Siu,Ian Perrone,Twaritha Vijay,Aayami Jain,Kristina Krassovsky,William M. Matern,Premanjali Lahiri,Ryan Rodriguez,Jason Skowronski,Arpit Batish,Dana Margittai,Prachi Wani,Timothy Van Horn,Claudia Flautero,Rosalva Flores,Jade Lee,Keri Tate,Maria Grazia Roncarolo,Steven Feldman,John F. DiPersio,Matthew H. Porteus +39 more
TL;DR: Nulabeglogene autogedtemcel (nula-cel) is an investigational drug product in which HDR-editing of plerixafor-mobilized CD34+ HSPCs in patients with SCD corrects the underlying variant that causes SCD, the first drug to directly correct a disease-causing variant.
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Functional screening in human HSPCs identifies optimized protein-based enhancers of Homology Directed Repair
Juan A. Perez-Bermejo,Oghene Efagene,William M Matern,Jeffrey K. Holden,Shaheen Kabir,Glen M. Chew,Gaia Andreoletti,Eniola Catton,Craig L. Ennis,Trevor L. Gerstenberg,Kaisle A. Hill,Kristina Krassovsky,Cassandra D. Lalisan,Daniel Lord,B. J. Quejarro,Jade Sales-Lee,Meet Shah,Brian J Silva,Jason Skowronski,Yuri G. Strukov,Joshua Thomas,Michael Veraz,Twaritha Vijay,Kirby A. Wallace,Jane Grogan,Beeke Wienert,Premanjali Lahiri,Sebastian Treusch,Daniel P. Dever,Vanessa B. Soros,James R. Partridge,Kristen L Seim +31 more
TL;DR: Researchers develop a functional screening platform to identify protein-based enhancers of Homology Directed Repair (HDR) in human hematopoietic stem and progenitor cells, discovering optimized variants that increase HDR efficiency and reduce off-target editing.
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Single-Cell RNA Sequencing of Sickle Cell Reticulocytes to Identify Beta-Globin Genotypes and Associated Gene Expression Differences
Sebastian Treusch,Twaritha Vijay,William M. Matern,Kristina Krassovsky,Vincent Siu,Ian Perrone,Glen M. Chew,Jane Grogan,Alana G. Lerner +8 more
TL;DR: In this article , a single-cell RNA sequencing (scRNAseq) method was developed to enable enumeration of potential gene-editing outcomes in peripheral reticulocytes.
Novel insights from a multiomics dissection of the Hayflick limit
Michelle Chan,Han Yuan,Ilya Soifer,Tobias M. Maile,Rebecca Y. Wang,Andrea T. Ireland,Jonathon J. O’Brien,Jérôme Goudeau,Leanne Jg Chan,Twaritha Vijay,Adam Freund,Cynthia Kenyon,Bryson D. Bennett,Fiona E. McAllister,David R. Kelley,Margaret Ann Roy,Robert L. Cohen,Arthur D. Levinson,David Botstein,David G. Hendrickson +19 more
TL;DR: It is demonstrated that senescent WI-38 cells acquire a striking resemblance to myofibroblasts in a process similar to the epithelial to mesenchymal transition (EMT) that is regulated by t YAP1/TEAD1 and TGF-β2.