Tuomas Mäkelä
University of Oulu
13 Papers
78 Citations
Tuomas Mäkelä is an academic researcher from University of Oulu. The author has contributed to research in topics: Ischemic preconditioning & Mesenchymal stem cell. The author has an hindex of 8, co-authored 13 publications. Previous affiliations of Tuomas Mäkelä include Oulu University Hospital.
Chat about Author
Papers
Remote Ischemic Preconditioning Protects the Brain Against Injury After Hypothermic Circulatory Arrest
Hanna Jensen,Stavros P. Loukogeorgakis,Fredrik Yannopoulos,Eija Rimpiläinen,Axel Petzold,Hannu Tuominen,Pasi Lepola,Raymond J. MacAllister,John E. Deanfield,Tuomas Mäkelä,Kirsi Alestalo,Kai Kiviluoma,Vesa Anttila,Victor Tsang,Tatu Juvonen +14 more
TL;DR: Data demonstrate that RIPC protects the brain against HCA-induced injury, resulting in accelerated recovery of neurological function, and might be neuroprotective in patients undergoing surgery with HCA and improve long-term outcomes.
Transient Proteolytic Modification of Mesenchymal Stromal Cells Increases Lung Clearance Rate and Targeting to Injured Tissue
Erja Kerkelä,Tanja Hakkarainen,Tuomas Mäkelä,Mari Raki,Oleg Kambur,Lotta Kilpinen,Janne Nikkilä,Siri Lehtonen,Ilja Ritamo,Roni Pernu,Mika Pietilä,Reijo Takalo,Tatu Juvonen,Kim Bergström,Eija Kalso,Leena Valmu,Saara Laitinen,Petri Lehenkari,Johanna Nystedt +18 more
TL;DR: It is shown that an alternative cell detachment of mesenchymal stromal/stem cells (MSCs) with pronase instead of trypsin significantly accelerated the lung clearance of the cells and, importantly, increased their targeting to an area of injury.
39
Improved cerebral recovery from hypothermic circulatory arrest after remote ischemic preconditioning.
Fredrik Yannopoulos,Tuomas Mäkelä,Eija Niemelä,Hannu Tuominen,Pasi Lepola,Kirsi Alestalo,Hanna Kaakinen,Kai Kiviluoma,Vesa Anttila,Tatu Juvonen +9 more
TL;DR: The data imply that remote ischemic preconditioning improves the recovery from HCA, and provides a faster recovery of cortical neuronal activity and protection against potential oxygen radical-mediated ischemia damage during and after HCA.
23
Intestinal bacterial translocation and tight junction structure in acute porcine pancreatitis.
Sanna Meriläinen,Jussi Mäkelä,Koivukangas,Hanna Jensen,Eija Rimpiläinen,Fredrik Yannopoulos,Tuomas Mäkelä,Kirsi Alestalo,Merja Vakkala,Juha Koskenkari,Pasi Ohtonen,Markku Koskela,Petri Lehenkari,Tuomo J. Karttunen,Tatu Juvonen +14 more
TL;DR: The major finding of this study was that bacterial translocation from the gut is not present at the beginning of acute pancreatitis and tight junction proteins claudin-2 and -5 do not become altered in the early stages of pancreatitis.
18
High number of transplanted stem cells improves myocardial recovery after AMI in a porcine model
Kirsi Alestalo,Riikka M Korpi,Jussi Mäkelä,Siri Lehtonen,Tuomas Mäkelä,Fredrik Yannopoulos,Kari Ylitalo,Marianne Haapea,Tatu Juvonen,Vesa Anttila,Elisa Lappi-Blanco,Roberto Blanco Sequeiros,Petri Lehenkari +12 more
TL;DR: The quantity of transplanted BMMNCs correlated with the improvement in cardiac function after AMI and improvement in EF was associated with the number of transplants detected in the myocardium.
14