Tugrul T. Kararli
G. D. Searle & Company
22 Papers
265 Citations
Tugrul T. Kararli is an academic researcher from G. D. Searle & Company. The author has contributed to research in topics: Transdermal & Intestinal absorption. The author has an hindex of 12, co-authored 22 publications. Previous affiliations of Tugrul T. Kararli include Pharmacia.
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Papers
Comparison of the gastrointestinal anatomy, physiology, and biochemistry of humans and commonly used laboratory animals
TL;DR: In addition to metabolic differences, the anatomical, physiological, and biochemical differences in the gastrointestinal (G.I.) tract of the human and common laboratory animals can cause significant variation in drug absorption from the oral route.
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Oral delivery of a renin inhibitor compound using emulsion formulations.
Tugrul T. Kararli,Thomas E. Needham,Marty Griffin,Grant L. Schoenhard,Ferro Leonard J,Lisa Alcorn +5 more
TL;DR: The results suggest that in the intestine of the animals, the particle size of the emulsions is reduced in the presence of bile fluid while the drug resides primarily in the oil phase.
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Enhancement of transdermal transport of azidothymidine (AZT) with novel terpene and terpene-like enhancers: In vivo-in vitro correlations
TL;DR: The in vitro and in vivo studies indicate the potential of t-anethole, carvacrol, thymol and linalool as effective transdermal enhancers and the feasibility of delivering significant amounts of AZT through the skin.
59
Solid-state interaction of magnesium oxide and ibuprofen to form a salt.
TL;DR: Comparison of the DSC, TGA, and MIR data for the reacted ib uprofen and MgO mixtures and synthetic Mg(ibuprofen)2 indicated that MgMgO and ibUprofen react to form the Mg salt of ibUProfen.
59
Reduced Systemic Availability of an Antiarrhythmic Drug, Bidisomide, with Meal Co-administration: Relationship with Region-Dependent Intestinal Absorption
Li-Heng Pao,Simon Zhou,Chyung S. Cook,Tugrul T. Kararli,Carol F. Kirchhoff,James E. Truelove,Aziz Karim,David Fleisher +7 more
TL;DR: The significant reduction in bidisomide plasma levels observed with meal co-administration in human subjects was predominantly mediated through a reduction in drug absorption and was independent of solid meal composition.