Tuanjun Hu
University of Edinburgh
20 Papers
71 Citations
Tuanjun Hu is an academic researcher from University of Edinburgh. The author has contributed to research in topics: Antibody & Receptor. The author has an hindex of 10, co-authored 18 publications. Previous affiliations of Tuanjun Hu include Newbury College.
Chat about Author
Papers
Direct allele introgression into pure chicken breeds using Sire Dam Surrogate (SDS) mating.
Maeve Ballantyne,Mark Woodcock,Dadakhalandar Doddamani,Tuanjun Hu,Lorna Taylor,Rachel Hawken,Michael J. McGrew +6 more
TL;DR: In this paper, the Sire Dam Surrogate (SDS) mating was used to reproduce the donor chicken breed carrying the edited allele in a single generation using the SDS surrogate hosts.
Chicken CCR6 and CCR7 are markers for immature and mature dendritic cells respectively.
TL;DR: After DC maturation following stimulation with LPS or CD40L, expression levels of ch CCR6 mRNA were down-regulated, whereas those of chCCR7 were up- regulated, suggesting that these two chemokine receptors play a similar role in the trafficking of chicken DC as they do in mammals and that they act as markers of immature (chCCR6) and mature (ch CCR7) DC.
49
Chicken CD14, unlike mammalian CD14, is trans-membrane rather than GPI-anchored
TL;DR: A cDNA encoding the chicken homologue of the human myelomonocytic differentiation antigen, CD14, was cloned by RT-PCR from chicken bone marrow cell RNA, using oligonucleotide primers based on the predicted cDNA sequence to suggest that chCD14 was potentially a trans-membrane protein.
Regulation and function of macrophage colony-stimulating factor (CSF1) in the chicken immune system.
Zhiguang Wu,Rakhi Harne,Cosmin Chintoan-Uta,Tuanjun Hu,Robert Wallace,Amanda MacCallum,Mark P. Stevens,Peter K. Kaiser,Adam Balic,David A. Hume +9 more
TL;DR: Using the anti-CSF1 antibodies, it is shown that chicken bone marrow derived macrophages (BMDM) express CSF1 on their surface, and that the level appears to be regulated further by exogenous CSF2, while in vitro treatment impacted on some tissue macrophage populations, but not blood monocytes.
29
Chicken interleukin-21 is costimulatory for T cells and blocks maturation of dendritic cells.
TL;DR: ChIL-21 synergistically enhances T-cell proliferation and inhibits maturation of dendritic cells, as in mammals, and is expressed in most lymphoid tissues, predominantly by CD4+ TCRαβ+ T cells.