Tsuyoshi Ishimoto
Taisho Pharmaceutical Co.
5 Papers
44 Citations
Tsuyoshi Ishimoto is an academic researcher from Taisho Pharmaceutical Co.. The author has contributed to research in topics: Kidney & Excretion. The author has an hindex of 5, co-authored 5 publications.
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Papers
HET0016, a potent and selective inhibitor of 20-HETE synthesizing enzyme
Noriyuki Miyata,Kazuo Taniguchi,Takayuki Seki,Tsuyoshi Ishimoto,Mariko Sato-Watanabe,Yoshiko Yasuda,Mariko Doi,Shunichi Kametani,Yasumitsu Tomishima,Tomokazu Ueki,Masakazu Sato,Kazuya Kameo +11 more
TL;DR: Results indicate that HET0016 is a potent and selective inhibitor of CYP enzymes responsible for the formation of 20‐HETE in man and rat.
Effects of a 20-HETE antagonist and agonists on cerebral vascular tone
Ming Yu,Liana Cambj-Sapunar,Franz Kehl,Kristopher G. Maier,Kazuhiko Takeuchi,Noriyuki Miyata,Tsuyoshi Ishimoto,L. Manmohan Reddy,John R. Falck,Debebe Gebremedhin,David R. Harder,Richard J. Roman +11 more
TL;DR: It is suggested that blocking the vasoconstrictor actions of 20-HETE may be useful to prevent the acute fall in cerebral blood flow following subarachnoid hemorrhage and to increase cerebral vascular tone both in vivo and in vitro.
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20-hydroxyeicosatetraenoic acid (20-HETE): structural determinants for renal vasoconstriction.
Ming Yu,Magdalena Alonso-Galicia,Chengwen Sun,Richard J. Roman,Naoya Ono,Hitomi Hirano,Tsuyoshi Ishimoto,Y. Krishna Reddy,Kishta Reddy Katipally,Komandla Malla Reddy,V. Raj Gopal,Ji Yu,Mohamed Takhi,John R. Falck +13 more
TL;DR: A putative binding domain map of the 20-HETE receptor was constructed consisting of a comparatively open, hydrophilic binding site accommodating the C(1)-functionality; a hydrophobic trough spanning the olefins; and a shallow pocket containing a critical pi-pi binding site in the vicinity of the pi.
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Combination of TS-021 with metformin improves hyperglycemia and synergistically increases pancreatic β-cell mass in a mouse model of type 2 diabetes
Atsushi Tajima,Takashi Hirata,Kazuo Taniguchi,Yukiko Kondo,Sota Kato,Masako Saito-Hori,Tsuyoshi Ishimoto,Koji Yamamoto +7 more
TL;DR: The coadministration of TS-021 and metformin synergistically improved the islet morphology by increasing the circulating level of biologically active GLP-1, which is thought to result from two different mechanisms (namely, an increase in GLp-1 secretion and DPP-IV inhibition).
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Increased excretion of urinary 20-HETE in rats with cyclosporine-induced nephrotoxicity.
Takayuki Seki,Tsuyoshi Ishimoto,Takanobu Sakurai,Yoshiko Yasuda,Kazuo Taniguchi,Mariko Doi,Mariko Sato,Richard J. Roman,Noriyuki Miyata +8 more
TL;DR: Results indicate that CsA-induced nephrotoxicity in rats is associated with a marked elevation in the renal production of 20-HETE and that 20-Eicosatetraenoic acid may contribute to the pathophysiological condition