Trias Thireou
Agricultural University of Athens
41 Papers
139 Citations
Trias Thireou is an academic researcher from Agricultural University of Athens. The author has contributed to research in topics: Biology & Anopheles gambiae. The author has an hindex of 10, co-authored 35 publications. Previous affiliations of Trias Thireou include Foundation for Biomedical Research & Foundation for Research & Technology – Hellas.
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Papers
Anopheles gambiae odorant binding protein crystal complex with the synthetic repellent DEET: implications for structure-based design of novel mosquito repellents.
Katerina E. Tsitsanou,Trias Thireou,Christina E. Drakou,Konstantinos Koussis,M. V. Keramioti,Demetres D. Leonidas,Elias Eliopoulos,Kostas Iatrou,Spyros E. Zographos +8 more
TL;DR: The experimental results confirmed the modeling predictions indicating that structure-based modeling could facilitate the design of novel repellents with enhanced binding affinity and selectivity.
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Crystal and Solution Studies of the “Plus-C” Odorant-binding Protein 48 from Anopheles gambiae CONTROL OF BINDING SPECIFICITY THROUGH THREE-DIMENSIONAL DOMAIN SWAPPING
Katerina E. Tsitsanou,Christina E. Drakou,Trias Thireou,Anna Vitlin Gruber,Georgia Kythreoti,Abdussalam Azem,Dimitrios Fessas,Elias Eliopoulos,Kostas Iatrou,Spyros E. Zographos +9 more
TL;DR: The three-dimensional structure of an A. gambiae “Plus-C” group OBP (AgamOBP48), which exhibits the second highest expression levels in female antennae, is described, which represents the first example of a three- dimensional domain-swapped dimer in dipteran species.
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Performance evaluation of principal component analysis in dynamic FDG-PET studies of recurrent colorectal cancer
Trias Thireou,Ludwig G. Strauss,Antonia Dimitrakopoulou-Strauss,George Kontaxakis,Sotiris Pavlopoulos,Andres Santos +5 more
TL;DR: Performance evaluation of principal component analysis (PCA) of dynamic F-18-FDG-PET studies of patients with recurrent colorectal cancer shows that PCA supports the visual interpretation of dynamic PEG studies, facilitates the application of compartment modeling and is a promising quantification technique.
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2,2′-Dihydroxybenzophenones and their carbonyl N-analogues as inhibitor scaffolds for MDR-involved human glutathione transferase isoenzyme A1-1
Fereniki Perperopoulou,Petros G. Tsoungas,Trias Thireou,Vagelis Rinotas,Eleni Douni,Elias Eliopoulos,Nikolaos E. Labrou,Yannis D. Clonis +7 more
TL;DR: The MDR-involved human GSTA1-1, an important isoenzyme overexpressed in several tumors leading to chemotherapeutic-resistant tumour cells, has been targeted by 2,2'-dihydroxybenzophenones and some of their carbonyl N-analogues, as its potential inhibitors.
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Concluding the trilogy: The interaction of 2,2'-dihydroxy-benzophenones and their carbonyl N-analogues with human glutathione transferase M1-1 face to face with the P1-1 and A1-1 isoenzymes involved in MDR.
Nikolaos Georgakis,Dionisis A. Karagiannopoulos,Trias Thireou,Elias Eliopoulos,Nikolaos E. Labrou,Petros G. Tsoungas,Michael Koutsilieris,Yannis D. Clonis +7 more
TL;DR: The outcome of the isoenzyme trilogy identified good binder leads for the investigated GSTs involved in MDR, and 5‐ or 5‐Bromo‐ or phenyl‐substituted inhibitors, having a H‐bonded oxime weakly acidic group of a small volume, are optimal candidates for binding hGSTM1‐1.
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