Trevor Douglas
Indiana University
264 Papers
2.8K Citations
Trevor Douglas is an academic researcher from Indiana University. The author has contributed to research in topics: Chemistry & Biology. The author has an hindex of 70, co-authored 252 publications. Previous affiliations of Trevor Douglas include Brown University & Ulsan National Institute of Science and Technology.
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Papers
Photo-induced H2 production by [NiFe]-hydrogenase from T. roseopersicina covalently linked to a Ru(II) photosensitizer
Oleg A. Zadvornyy,Oleg A. Zadvornyy,Janice Lucon,Robin Gerlach,Nikolay A. Zorin,Trevor Douglas,Timothy E. Elgren,John W. Peters +7 more
TL;DR: This work demonstrates photo-induced hydrogen production from a stable [NiFe]-hydrogenase coupled to a [Ru(2,2'-bipyridine)(2)(5-amino-1,10-phenanthroline)](2+) photocatalyst and provides a strong proof of concept for engineering photocatalytic hydrogen production in the presence of oxygen using biohybrid mimetic systems.
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Higher order assembly of virus-like particles (VLPs) mediated by multi-valent protein linkers.
Masaki Uchida,Masaki Uchida,Ben LaFrance,Chris C. Broomell,Peter E. Prevelige,Trevor Douglas,Trevor Douglas +6 more
TL;DR: Higher order assembly of virus-like particles derived from the bacteriophage P22 is demonstrated by using a small adaptor protein, Dec, which binds to symmetry specific sites on the P22 capsid, while Dec with only a single binding site does not mediate P22 assembly.
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Induction of Antiviral Immune Response through Recognition of the Repeating Subunit Pattern of Viral Capsids Is Toll-Like Receptor 2 Dependent.
Kelly M. Shepardson,Benjamin Schwarz,Kyle Larson,Rachelle V. Morton,John Avera,Kimberly McCoy,Alayna Caffrey,Ann L. Harmsen,Trevor Douglas,Agnieszka Rynda-Apple +9 more
TL;DR: It is found that an initial antiviral immune response is induced by the repeating subunit pattern of virus exteriors (capsids), and thus, induction of this response is independent of viral infection.
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A click chemistry based coordination polymer inside small heat shock protein.
Janice Lucon,Joynal Abedin,Masaki Uchida,Lars O. Liepold,Craig Jolley,Mark J. Young,Trevor Douglas +6 more
TL;DR: A branched iron-phenanthroline based coordination polymer has been constructed in a water based system using a click chemistry approach to link monomeric coordination complexes together within a protein cage nanoarchitecture.
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Constructing catalytic antimicrobial nanoparticles by encapsulation of hydrogen peroxide producing enzyme inside the P22 VLP.
TL;DR: A self-assembling virus like particle is examined to construct catalytically active nanoparticles that can inhibit bacterial growth and suggest that encapsulation of enzymes inside VLPs can be exploited to develop new bionanomaterials with useful functionalities.
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