Trefa M Abdullah
University of Exeter
5 Papers
Trefa M Abdullah is an academic researcher from University of Exeter. The author has contributed to research in topics: Unfolded protein response & Endoplasmic reticulum. The author has an hindex of 4, co-authored 5 publications. Previous affiliations of Trefa M Abdullah include University of Sulaymaniyah.
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Papers
Mechanisms of Translocation of ER Chaperones to the Cell Surface and Immunomodulatory Roles in Cancer and Autoimmunity.
TL;DR: The evidence is evaluated for the different mechanisms of ER protein translocation and binding to the cell surface and how ERprotein translocation can act as a signal for cancer cells to undergo killing by immunogenic cell death and other cell death pathways.
Endoplasmic reticulum stress-induced release and binding of calreticulin from human ovarian cancer cells.
Trefa M Abdullah,Trefa M Abdullah,Jacqueline L. Whatmore,Edwin Bremer,Edwin Bremer,Rimantas Slibinskas,Marek Michalak,Marek Michalak,Paul Eggleton +8 more
TL;DR: In this paper, the authors investigated at what stage of cell viability, CRT appeared associated with surface of human ovarian cancers (OC) and found that ER stress is partially responsible for the changes in CRT cellular distribution.
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Investigation into the toxic effects of graphene nanopores on lung cancer cells and biological tissues
Tanveer A. Tabish,Zahidul Islam Pranjol,Zahidul Islam Pranjol,Farhat Jabeen,Trefa M Abdullah,Asif Latif,Adeel Khalid,Muhammad Ali,Hasan Hayat,Paul G. Winyard,Jacqueline L. Whatmore,Shaowei Zhang +11 more
TL;DR: Results show that GNPs are likely to have a low bioavailability in SKMES-1 and A549 lung cancer cells and rats, and a more long-term GNPs exposure regime, more relevant to real-life environmental consequences, is needed to fully determine the transport capacities of GNPs in living systems.
In vitro toxic effects of reduced graphene oxide nanosheets on lung cancer cells.
Tanveer A. Tabish,Zahidul Islam Pranjol,Hasan Hayat,Alma A. M. Rahat,Trefa M Abdullah,Jacqueline L. Whatmore,Shaowei Zhang +6 more
TL;DR: At low concentrations, rGO was shown to significantly produce late apoptosis and necrosis rather than early apoptotic events, suggesting that it was able to disintegrate the cellular membranes in a dose dependent manner.
Galectin-9 Is a Possible Promoter of Immunopathology in Rheumatoid Arthritis by Activation of Peptidyl Arginine Deiminase 4 (PAD-4) in Granulocytes
Valerie R. Wiersma,Alex Clarke,Simon D. Pouwels,Elizabeth Perry,Trefa M Abdullah,Clive Kelly,Anthony De Soyza,David Hutchinson,Paul Eggleton,Edwin Bremer +9 more
TL;DR: This study identifies for the first time an immunomodulatory protein, Gal-9, that triggers activation of granulocytes leading to increased PAD-4 expression and generation of citrullinated autoantigens in rheumatoid arthritis patients.