Tracy Fletcher
St Mary's Hospital
6 Papers
33 Citations
Tracy Fletcher is an academic researcher from St Mary's Hospital. The author has contributed to research in topics: Genetic testing & Medicine. The author has an hindex of 5, co-authored 6 publications. Previous affiliations of Tracy Fletcher include University of Saint Mary & Central Manchester University Hospitals NHS Foundation Trust.
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Papers
Clinical utility of genetic testing in 201 preschool children with inherited eye disorders.
Eva Lenassi,Eva Lenassi,Jill Clayton-Smith,Jill Clayton-Smith,Sofia Douzgou,Sofia Douzgou,Simon C Ramsden,Simon C Ramsden,Stuart Ingram,Georgina Hall,Georgina Hall,Claire Hardcastle,Tracy Fletcher,Rachel L. Taylor,Rachel L. Taylor,Jamie M Ellingford,Jamie M Ellingford,William D Newman,Cecilia Fenerty,Cecilia Fenerty,Vinod Kumar Sharma,I Chris Lloyd,I Chris Lloyd,Susmito Biswas,Susmito Biswas,Jane Ashworth,Jane Ashworth,Graeme C.M. Black,Graeme C.M. Black,Panagiotis I. Sergouniotis,Panagiotis I. Sergouniotis,Panagiotis I. Sergouniotis +31 more
TL;DR: Genetic testing helped identify an etiological diagnosis in the majority of preschool children with IEDs, which prevented additional unnecessary testing and provided the opportunity for anticipatory guidance in significant subsets of patients.
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Clinical and genetic variability in children with partial albinism.
Patrick Campbell,Jamie M Ellingford,Jamie M Ellingford,Neil R. A. Parry,Tracy Fletcher,Simon C Ramsden,Theodora Gale,Georgina Hall,Katherine A. Smith,Dalia Kasperaviciute,Ellen R A Thomas,I Chris Lloyd,I Chris Lloyd,Sofia Douzgou,Sofia Douzgou,Jill Clayton-Smith,Jill Clayton-Smith,Susmito Biswas,Jane Ashworth,Graeme C.M. Black,Graeme C.M. Black,Panagiotis I. Sergouniotis,Panagiotis I. Sergouniotis,Panagiotis I. Sergouniotis +23 more
TL;DR: The findings highlight that panel-based genetic testing is a clinically useful test with a high diagnostic yield in children with partial/ocular albinism.
A clinical molecular genetic service for United Kingdom families with choroideraemia.
Simon C Ramsden,Anna O'Grady,Tracy Fletcher,James O'Sullivan,Nikki Hart-Holden,Stephanie Barton,Georgina Hall,Anthony T. Moore,Andrew R. Webster,Graeme C.M. Black +9 more
TL;DR: Clinical molecular testing for CHM is available clinically and can be used to support the clinical diagnosis and management of patients with choroideraemia as well as their families and the potential clinical utility of testing is demonstrated.
21
•Journal Article
Severe retinal degeneration in women with a c.2543del mutation in ORF15 of the RPGR gene
Bohdan Kousal,Pavlina Skalicka,Lucie Valesova,Tracy Fletcher,Niki Hart-Holden,Anna O’Grady,Christina Chakarova,Michel Michaelides,Alison J. Hardcastle,Petra Liskova +9 more
TL;DR: The c.2543del mutation in ORF15 of RPGR is associated with a severe phenotype in the women in this family and the presence of a significant myopic refractive error, in the absence of male-to-male transmission, may be indicative of X-linked inheritance.
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EyeG2P: an automated variant filtering approach improves efficiency of diagnostic genomic testing for inherited ophthalmic disorders.
Eva Lenassi,Eva Lenassi,Eva Lenassi,Ana Carvalho,Anja Thormann,Tracy Fletcher,Claire Hardcastle,Sarah E. Hunt,Panagiotis I. Sergouniotis,Panagiotis I. Sergouniotis,Panagiotis I. Sergouniotis,Michel Michaelides,Michel Michaelides,Andrew R Webster,Andrew R Webster,Fiona Cunningham,Simon C Ramsden,David R. FitzPatrick,Graeme C.M. Black,Graeme C.M. Black,Jamie M Ellingford,Jamie M Ellingford +21 more
TL;DR: EyeG2P as discussed by the authors is a publically available resource to assist diagnostic filtering of genomic datasets for ophthalmic conditions, utilising the Ensembl Variant Effect Predictor, which enabled a significant increase in precision in comparison to routine testing strategies.