Toula Bouras
Georgetown University
5 Papers
86 Citations
Toula Bouras is an academic researcher from Georgetown University. The author has contributed to research in topics: Cyclin D1 & Cyclin D. The author has an hindex of 5, co-authored 5 publications. Previous affiliations of Toula Bouras include University of Washington.
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Papers
SIRT1 deacetylation and repression of p300 involves lysine residues 1020/1024 within the cell cycle regulatory domain 1.
Toula Bouras,Maofu Fu,Anthony A. Sauve,Fang Wang,Andrew A. Quong,Neil D. Perkins,Ronald T. Hay,Wei Gu,Richard G. Pestell +8 more
TL;DR: The p300 protein serves as a rate-limiting transcriptional cointegrator of diverse transcription factors either to activate or to repress transcription through modular subdomains and may serve an important integration point during metabolism and cellular differentiation.
366
Signal transduction mediated by cyclin D1: from mitogens to cell proliferation: a molecular target with therapeutic potential.
TL;DR: The basic regulatory machinery responsible for cell cycle control and the latest advances made in the field are outlined and strategies for targeting cyclin D1 and cyclinD1-mediated signaling pathways as means of developing novel and perhaps more effective anticancer treatments are discussed.
95
Cyclin D1 Represses p300 Transactivation through a Cyclin-dependent Kinase-independent Mechanism
Maofu Fu,Chenguang Wang,Mahadev Rao,Xiaofang Wu,Toula Bouras,Xueping Zhang,Zhiping Li,Xuanmao Jiao,Jianguo Yang,Anping Li,Neil D. Perkins,Bayar Thimmapaya,Andrew L. Kung,Alberto Muñoz,Antonio Giordano,Michael P. Lisanti,Richard G. Pestell +16 more
TL;DR: It is shown that cyclin D1 physically interacts with p300 and represses p300 transactivation, and that the interaction of the two proteins occurs at the peroxisome proliferator-activated receptor γ-responsive element of the lipoprotein lipase promoter in the context of the local chromatin structure.
91
Caveolin-1 in breast cancer.
TL;DR: This review concentrates on recent advances implicating caveolin-1 in breast cancer pathogenesis, with emphasis on the signaling pathways regulated during these processes.
61
Cyclin D1 Inhibits Peroxisome Proliferator-activated Receptor γ-mediated Adipogenesis through Histone Deacetylase Recruitment
Maofu Fu,Mahadev Rao,Toula Bouras,Chenguang Wang,Kongming Wu,Xueping Zhang,Zhiping Li,Tiso-Pang Yao,Richard G. Pestell +8 more
TL;DR: An important role of cyclin D1 is suggested in regulation of PPARγ-mediated adipocyte differentiation through recruitment of HDACs to regulate PPAR response element local chromatin structure andPPARγ function.