Tore K Kvien

Abstract: Objective: The rheumatoid arthritis impact of disease (RAID) questionnaire comprises seven patient-important domains of disease impact (pain, function, fatigue, sleep disturbance, emotional well-being, physical well-being, coping) RAID was validated as a pooled-weighted score Its seven individual items separately could provide a valuable tool in clinical practice to guide interventions targeting the patient's experience of the disease The aim was to separately assess the psychometric properties of each of the seven numeric rating scale (NRS) of the RAID (RAID7) Material and methods: Post hoc analyses of data from the cross-sectional RAID study and from the Rainbow study, an open-label 12-week trial of etanercept in patients with RA Construct validity of each NRS was assessed cross-sectionally in the RAID data set by Spearman's correlation with the respective external instrument of reference Using the rainbow data set, we assessed reliability through intraclass correlation coefficient between the screening and the baseline visits and responsiveness (sensitivity to change) by standardised response mean between baseline and 12 weeks Results: A total of 671 patients with RA with features of established disease were analysed, 563 and 108 from RAID and Rainbow, respectively The NRS correlated moderately to strongly with the respective external instrument of reference (r=062-081) Reliability ranged from 064 (051-074) (pain) to 083 (076-088) (sleep disturbance) and responsiveness from 093 (073-113) (sleep disturbance) to 134 (101-164) (pain) Conclusion: The separate use of the individual NRS of RAID (RAID7) is valid, feasible, reliable and sensitive to change, representing an opportunity to improve the assessment and treatment of disease impact with minimal questionnaire burden

TL;DR: Both pharmacological and nonpharmacological treatment modalities are important, but the choice of therapy in individual patients must take into account evidence for effectiveness and individual factors.

TL;DR: The 2-year disease course in patients with undifferentiated arthritis (UA) focusing on fulfillment of the 2010 American College of Rheumatology/European League Against Rheumatism (ACR/EULAR) rheumatoid arthritis (RA) classification criteria was examined to examine the factors associated with RA development.

TL;DR: The overall physical function measured by AIMS2 physical and MHAQ deteriorated more than upper limb function over a 10‐year period in patients with established RA.