Tony Velkov
University of Melbourne
252 Papers
1K Citations
Tony Velkov is an academic researcher from University of Melbourne. The author has contributed to research in topics: Polymyxin & Polymyxin B. The author has an hindex of 39, co-authored 214 publications. Previous affiliations of Tony Velkov include Northeast Agricultural University & Monash University, Parkville campus.
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Papers
Global metabolic analyses identify key differences in metabolite levels between polymyxin-susceptible and polymyxin-resistant Acinetobacter baumannii
Mohd Hafidz Mahamad Maifiah,Soon-Ee Cheah,Matthew D. Johnson,Mei-Ling Han,John D. Boyce,Visanu Thamlikitkul,Alan Forrest,Keith S. Kaye,Paul J. Hertzog,Paul J. Hertzog,Anthony W. Purcell,Jiangning Song,Tony Velkov,Darren J. Creek,Jian Li +14 more
TL;DR: This is the first comparative untargeted metabolomics study to show substantial differences in the metabolic profiles of the polymyxin-susceptible and -resistant A. baumannii.
Synergistic Combination of Polymyxin B and Enrofloxacin Induced Metabolic Perturbations in Extensive Drug-Resistant Pseudomonas aeruginosa.
Yu-Wei Lin,Mei-Ling Han,Jinxin Zhao,Yan Zhu,Gauri Rao,Alan Forrest,Jiangning Song,Keith S Kaye,Paul J. Hertzog,Anthony W. Purcell,Darren J. Creek,Qi Tony Zhou,Tony Velkov,Jian Li +13 more
TL;DR: The metabolomics approach taken in this study highlights its power to elucidate the mechanism of synergistic killing by antibiotic combinations at the systems level and significantly minimized polymyxin resistance via the inhibition of lipid A modification pathway.
Colistin-Induced Apoptosis of Neuroblastoma-2a Cells Involves the Generation of Reactive Oxygen Species, Mitochondrial Dysfunction, and Autophagy.
TL;DR: Colistin-induced neuronal cell death involves ROS-mediated oxidative stress and mitochondrial dysfunction, followed by caspase-dependent apoptosis and autophagy, which could be attenuated by co-treatment with the pan-caspase inhibitor Z-VAD-FMK.
Probing the penetration of antimicrobial polymyxin lipopeptides into gram-negative bacteria.
Zakuan Zainy Deris,James D. Swarbrick,Kade D. Roberts,Mohammad Abul Kalam Azad,Jesmin Akter,Andrew S. Horne,Roger L. Nation,Kelly L. Rogers,Philip E. Thompson,Tony Velkov,Jian Li +10 more
TL;DR: The regioselective modification of the polymyxin B core scaffold at the N-terminus with the dansyl fluorophore is reported to generate an active probe that mimics polymy Xin B pharmacologically, which will advance the development of platforms for the discovery of novel polymyXin lipopeptides with efficacy against poly myxin-resistant strains.
Developing an Anion Host for Lipid A Binding and Antibacterial Activity.
TL;DR: New structural amphiphiles (I) bind the diphosphate lipid A anion and show potential as lead compounds for the development of novel antibacterial agents.