Tony Velkov
University of Melbourne
252 Papers
1K Citations
Tony Velkov is an academic researcher from University of Melbourne. The author has contributed to research in topics: Polymyxin & Polymyxin B. The author has an hindex of 39, co-authored 214 publications. Previous affiliations of Tony Velkov include Northeast Agricultural University & Monash University, Parkville campus.
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Papers
Inwardly rectifying potassium channels mediate polymyxin-induced nephrotoxicity
Jing Lu,Abul Kalam Azad,Julie L. M. Moreau,Yan Zhu,Xukai Jiang,Mary A Tonta,Rachel Lam,Hasini Wickremasinghe,Jinxin Zhao,Jiping Wang,Harold A. Coleman,Luke E. Formosa,Tony Velkov,Helena C. Parkington,Alexander N. Combes,Joseph Rosenbluh,Jian Li +16 more
TL;DR: In this article , the authors employed a whole-genome CRISPR screen in human kidney tubular HK-2 cells and identified 86 significant genes that upon knock-out rescued polymyxin-induced toxicity.
Design and Evaluation of Novel Polymyxin Fluorescent Probes
TL;DR: Two novel fluorescent polymyxin probes were designed through regio-selective modifications of the polymyXin B core structure at the N-terminus and the hydrophobic motif at positions 6 and 7 and should prove to be of considerable utility for imaging cellular uptake and mechanistic investigations of these important last-line antibiotics.
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Sialylation of Asparagine 612 inhibits Aconitase activity during mouse sperm capacitation; A possible mechanism for the switch from oxidative phosphorylation to glycolysis
Ana Izabel Silva Balbin Villaverde,Rachel A Ogle,Peter J. Lewis,Vincenzo Carbone,Tony Velkov,Jacob Netherton,Mark Baker +6 more
TL;DR: It is shown that the mitochondrial enzyme Aconitase becomes sialylated during capacitation, which may be a mechanism by which sperm switch from an oxidative to glycolytic dependent cell after ejaculation.
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Generation of mutant leukaemia inhibitory factor (LIF)–IgG heavy chain fusion proteins as bivalent antagonists of LIF
Jalal A. Jazayeri,Nicole Anne De Weerd,Warren Sean Raye,Tony Velkov,Leilani Llanes Santos,David Taylor,Graeme J Carroll +6 more
TL;DR: Preliminary pharmacokinetics indicates that the Fc fusion constructs have a longer serum half-life compared to their non-fusion counterparts.
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•Journal Article
Polymyxin B causes DNA damage in HK-2 cells and mice (vol 92, pg 2259, 2018)
Bo Yun,Tao Zhang,Mak Azad,Jiping Wang,Cameron J. Nowell,Paul Kalitsis,Tony Velkov,Damien F. Hudson,Jian Li +8 more
TL;DR: Results indicate that polymyxin B nephrotoxicity is associated with DNA damage, leading to chromosome missegregation and genome instability, which may lead to new strategies to overcome the neph rotoxicity of this important last-line class of antibiotics.
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