Tony Velkov
University of Melbourne
252 Papers
1K Citations
Tony Velkov is an academic researcher from University of Melbourne. The author has contributed to research in topics: Polymyxin & Polymyxin B. The author has an hindex of 39, co-authored 214 publications. Previous affiliations of Tony Velkov include Northeast Agricultural University & Monash University, Parkville campus.
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Papers
Design, synthesis, and evaluation of a new fluorescent probe for measuring polymyxin-lipopolysaccharide binding interactions
Rachel L. Soon,Tony Velkov,Tony Velkov,Francis C. K. Chiu,Philip E. Thompson,Rashmi Kancharla,Kade D. Roberts,Ian Larson,Roger L. Nation,Jian Li +9 more
TL;DR: The affinity of polymyxin for purified gram-negative LPS and whole bacterial cells was investigated and a mono-substituted fluorescent derivative, dansyl[Lys]¹polymyx in B₃ may prove useful as a screening tool for drug development.
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Analysis of Phosphopeptide Changes as Spermatozoa Acquire Functional Competence in the Epididymis Demonstrates Changes in the Post-translational Modification of Izumo1
Mark Baker,Louise Hetherington,Anita Weinberg,Nenad Naumovski,Tony Velkov,Matthias Pelzing,Sebastiaan Dolman,Mark R. Condina,R. John Aitken +8 more
TL;DR: A model is advanced suggesting that these phospho-regulations are likely to act as a scaffold for the association of adaptor proteins with Izumo1 as these cells prepare for fertilization.
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Polymyxins-Curcumin Combination Antimicrobial Therapy: Safety Implications and Efficacy for Infection Treatment
TL;DR: For the clinical translation of this combination to become a reality, further research is required to develop novel polymyxins–curcumin formulations with optimized pharmacokinetics and dosage regimens.
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The thermodynamics of Pr55Gag-RNA interaction regulate the assembly of HIV.
Hanumantsingh Tanwar,Hanumantsingh Tanwar,Keith K. Khoo,Keith K. Khoo,Megan Garvey,Megan Garvey,Lynne J. Waddington,Andrew Leis,Marcel Hijnen,Tony Velkov,Geoff Dumsday,William J. McKinstry,Johnson Mak,Johnson Mak +13 more
TL;DR: The data provide direct evidence on how nucleic acid sequences and the oligomeric state of Pr55Gag regulate HIV assembly and imply the stepwise increments of heat being released during HIV biogenesis may help to facilitate the process of viral assembly.
Structure–Activity Relationships of Daptomycin Lipopeptides
John A. Karas,Glen P. Carter,Benjamin P Howden,Adrianna M. Turner,Olivia K. A. Paulin,James D. Swarbrick,Mark Baker,Jian Li,Tony Velkov +8 more
TL;DR: This review is to provide the most comprehensive and up-to-date reference for the medicinal chemist on the structure-activity-toxicity of this important class of lipopeptide antibiotics.
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