Toni Hoffmann
University of Leeds
16 Papers
181 Citations
Toni Hoffmann is an academic researcher from University of Leeds. The author has contributed to research in topics: Force spectroscopy & Protein engineering. The author has an hindex of 14, co-authored 16 publications. Previous affiliations of Toni Hoffmann include St James's University Hospital & Martin Luther University of Halle-Wittenberg.
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Papers
Identification of a regulatory pathway that controls the heavy-metal resistance system Czc via promoter czcNp in Ralstonia metallidurans.
TL;DR: Double- and multiple-deletion studies demonstrated that four regulators encoded downstream of the czcCBA operon, including the transport protein CzcD, the two-component regulatory system Cz cR, CzCS, and the periplasmic metal-binding protein CZcE exert metal-dependent control of czcNICBA expression via regulation of czCNp activity.
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Capacity of Salvinia minima Baker to Tolerate and Accumulate As and Pb
TL;DR: The use of Salvinia minima Baker for the removal of lead (Pb) and arsenic (As) from aqueous solutions was investigated in this paper, where the effect of different concentrations of AsO 4 3- and Pb(II) on the growth and accumulation of these metals was studied.
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Paralogs of genes encoding metal resistance proteins in Cupriavidus metallidurans strain CH34.
TL;DR: Genome sequence analysis revealed the presence of a variety of paralogs of proteins that were previously shown to be involved in heavy metal resistance in C. metallidurans strain CH34, an advantage that may compensate for the costs of maintaining these genes during evolution.
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First step towards a quantitative model describing Czc-mediated heavy metal resistance in Ralstonia metallidurans.
Antje Legatzki,Sylvia Franke,Susann Lucke,Toni Hoffmann,Andreas Anton,Dieter Neumann,Dietrich H. Nies +6 more
TL;DR: It was possible to simulate physiological events in growing cells by quantitative models that are derived from the biochemical data of the interacting transport proteins, and described cadmium resistance sufficiently for R. metallidurans growing in the presence of 0.2–1 mM Cd2+.
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Structure-function studies of an engineered scaffold protein derived from stefin A. I: Development of the SQM variant
Toni Hoffmann,Lukas K. J. Stadler,Michael Busby,Qifeng Song,Anthony T. Buxton,Simon D. Wagner,Jason J. Davis,Paul Ko Ferrigno +7 more
TL;DR: Five new STM-based scaffold proteins that contain modifications designed to further improve the versatility of the authors' scaffold are described and one (stefin A quadruple mutant, SQM) was chosen as a versatile, stable scaffold.