15 Papers
108 Citations
Tong Gui is an academic researcher from University of North Carolina at Chapel Hill. The author has contributed to research in topics: Factor IX & Gla domain. The author has an hindex of 9, co-authored 14 publications.
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Papers
Circulating and binding characteristics of wild-type factor IX and certain Gla domain mutants in vivo.
Tong Gui,Hui Feng Lin,Da Yun Jin,Maureane Hoffman,David L. Straight,Harold R. Roberts,Darrel W. Stafford +6 more
TL;DR: It is demonstrated that factor IX binds in vivo to endothelial cell-collagen IV surfaces and plays a role in controlling factor IX concentration in the blood.
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Abnormal hemostasis in a knock-in mouse carrying a variant of factor IX with impaired binding to collagen type IV.
Tong Gui,Adili Reheman,Heyu Ni,Heyu Ni,Peter L. Gross,F. Yin,Dougald M. Monroe,Paul E. Monahan,Darrel W. Stafford +8 more
TL;DR: The results indicate that the FIX molecule with decreased affinity for collagen IV has altered hemostatic properties in vivo and that the binding of FIX to collagen IV probably plays a significant functional role in hemostasis.
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Creation of a mouse expressing defective human factor IX.
TL;DR: This work has created a human factor IX mouse model of hemophilia B (R333Q-hFIX mouse) by homologous recombination in embryonic stem cells and will complement the FIXKO mice for studying factor IX circulating kinetics and gene therapy.
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Integration-deficient Lentiviral Vectors Expressing Codon-optimized R338L Human FIX Restore Normal Hemostasis in Hemophilia B Mice
Thipparat Suwanmanee,Genlin Hu,Tong Gui,Cynthia C. Bartholomae,Ina Kutschera,Christof von Kalle,Manfred Schmidt,Paul E. Monahan,Tal Kafri +8 more
TL;DR: This study demonstrates that IDLVs carrying an improved human FIX cDNA safely and efficiently cure hemophilia B in a mouse model.
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Correction of factor IX deficiency in mice by embryonic stem cells differentiated in vitro
Jeffrey H. Fair,Bruce A. Cairns,Michael LaPaglia,Montserrat Caballero,W. Andrew Pleasant,Seigo Hatada,Hyung Suk Kim,Tong Gui,Larysa H. Pevny,Anthony A. Meyer,Darrel W. Stafford,Oliver Smithies,Jeffrey A. Frelinger +12 more
TL;DR: It is demonstrated that functional liver engraftment does occur if the ES cells (from strain 129 mice) are first differentiated in vitro for 7 days in the presence of FGF.
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