Tomoyuki Watanabe
Daiichi Sankyo
31 Papers
96 Citations
Tomoyuki Watanabe is an academic researcher from Daiichi Sankyo. The author has contributed to research in topics: Solubility & Recrystallization (metallurgy). The author has an hindex of 10, co-authored 31 publications.
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Papers
Solid State Radical Recombination and Charge Transfer across the Boundary between Indomethacin and Silica under Mechanical Stress
Tomoyuki Watanabe,Susumu Hasegawa,Naoki Wakiyama,Fusao Usui,Akira Kusai,Tetsuhiko Isobe,Mamoru Senna +6 more
TL;DR: In this article, a composite of indomethacin and SiO 2 was prepared in a solid state by cogrinding, and the resulting dehydration was observed as a consequence of a chemical reaction between silanol groups of SiO2 and carboxyl groups of IM.
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Prediction of apparent equilibrium solubility of indomethacin compounded with silica by 13C solid state NMR.
TL;DR: The apparent equilibrium solubility (AES) of indomethacin increased by co-grinding with silica primarily to the short range disorder on the molecular basis, and a high correlation between the standardized full width at half maximum of the specific peaks observed by 13C solid state NMR and log enables the prediction of AES.
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Verification of model development technique for NIR-based real-time monitoring of ingredient concentration during blending.
TL;DR: The results confirmed that the small prediction error was realized by a calibration set, including dynamic measurement spectra acquired with the target blender, and demonstrated that locally weighted partial least squares (LW-PLS) achieved the smaller prediction error than conventional PLS.
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Drug - carrier interaction in solid dispersions prepared by co-grinding and melt-quenching
TL;DR: In this article, les mecanismes de debut d'interaction entre un medicament and SiO 2 sous contraintes mecaniques, sur la base de changements dans les especes radicalaires, de formation de liaisons pontantes and de mise en ordre a courte distance.
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Spectral fluctuation dividing for efficient wavenumber selection: Application to estimation of water and drug content in granules using near infrared spectroscopy
TL;DR: The proposed SFD-PLS is a promising wavenumber selection method that divides a whole spectrum into multiple spectral intervals at local minimum points of the spectral fluctuation profile and was more than 25 times faster than iPLS.
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