Tomoo Owa
Tokyo Medical and Dental University
13 Papers
9 Citations
Tomoo Owa is an academic researcher from Tokyo Medical and Dental University. The author has contributed to research in topics: Cerebellum & Neuroepithelial cell. The author has an hindex of 6, co-authored 9 publications.
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Papers
Meis1 Coordinates Cerebellar Granule Cell Development by Regulating Pax6 Transcription, BMP Signaling and Atoh1 Degradation.
Tomoo Owa,Shinichiro Taya,Satoshi Miyashita,Mariko Yamashita,Toma Adachi,Koyo Yamada,Miwa Yokoyama,Shogo Aida,Tomoki Nishioka,Yukiko U. Inoue,Ryo Goitsuka,Takuro Nakamura,Takayoshi Inoue,Kozo Kaibuchi,Mikio Hoshino +14 more
TL;DR: It is suggested that the Meis1–Pax6 pathway increases the expression of Smad proteins to upregulate BMP signaling, leading to degradation of Atoh1 in the inner EGL, which contributes to differentiation from GCPs to GCs.
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Origins of oligodendrocytes in the cerebellum, whose development is controlled by the transcription factor, Sox9
Ryoya Hashimoto,Kei Hori,Tomoo Owa,Satoshi Miyashita,Ken-ichi Dewa,Norihisa Masuyama,Kazuhisa Sakai,Yoneko Hayase,Yusuke Seto,Yukiko U. Inoue,Takayoshi Inoue,Noritaka Ichinohe,Yoshiya Kawaguchi,Haruhiko Akiyama,Schuichi Koizumi,Mikio Hoshino +15 more
TL;DR: Evidence is obtained that the majority of oligodendrocytes in the cerebellum originate from the Olig2-expressing neuroepithelial domain in the ventral rhombomere 1 (r1), while about 6% of cerebellar oligodends are produced in the Cerebellar ventricular zone.
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Pathologic Active mTOR Mutation in Brain Malformation with Intractable Epilepsy Leads to Cell-Autonomous Migration Delay.
Sae Hanai,Sayuri Sukigara,Hongmei Dai,Tomoo Owa,Shin-ichi Horike,Taisuke Otsuki,Takashi Saito,Eiji Nakagawa,Naoki Ikegaya,Takanobu Kaido,Noriko Sato,Akio Takahashi,Kenji Sugai,Yuko Saito,Masayuki Sasaki,Mikio Hoshino,Yu-ichi Goto,Schuichi Koizumi,Masayuki Itoh +18 more
TL;DR: A novel somatic mutation of the MTOR gene is obtained, which resulted in hyperphosphorylation of its downstream molecules, S6 and 4E-binding protein 1, and delayed cell migration on the radial glial fiber and did not affect other cells.
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Cyclin D1 controls development of cerebellar granule cell progenitors through phosphorylation and stabilization of ATOH1.
Satoshi Miyashita,Tomoo Owa,Yusuke Seto,Mariko Yamashita,Shogo Aida,Masaki Sone,Kentaro Ichijo,Tomoki Nishioka,Kozo Kaibuchi,Yoshiya Kawaguchi,Shinichiro Taya,Mikio Hoshino +11 more
TL;DR: Wang et al. as discussed by the authors reported that cyclin D1 (CCND1) directly regulates both proliferative and immature states of cerebellar granule cell progenitors (GCPs).
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Expression of transcription factors and signaling molecules in the cerebellar granule cell development.
Ryo Shiraishi,Sathoshi Miyashita,Mariko Yamashita,Toma Adachi,Mana Shimoda,Tomoo Owa,Mikio Hoshino +6 more
TL;DR: Detailed immunostaining in the developing cerebellum is performed, with particular focus on GCPs and GCs, looking at several transcription factors, signaling molecules, cell cycle regulators, some of which are known to regulate neural development, to provide a basis for future studies on the cerebellar GC development and medulloblastoma.
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