Tomoko Ikeuchi
National Institutes of Health
17 Papers
28 Citations
Tomoko Ikeuchi is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Medicine & Receptor. The author has an hindex of 9, co-authored 14 publications. Previous affiliations of Tomoko Ikeuchi include Tohoku University.
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Papers
A dysbiotic microbiome triggers T H 17 cells to mediate oral mucosal immunopathology in mice and humans.
Nicolas Dutzan,Nicolas Dutzan,Tetsuhiro Kajikawa,Loreto Abusleme,Loreto Abusleme,Teresa Greenwell-Wild,Carlos E. Zuazo,Tomoko Ikeuchi,Laurie Brenchley,T. Abe,C. Hurabielle,C. Hurabielle,Daniel Martin,Robert J. Morell,Alexandra F. Freeman,Vanja Lazarevic,Giorgio Trinchieri,Patricia I. Diaz,Steven M. Holland,Yasmine Belkaid,George Hajishengallis,Niki M. Moutsopoulos +21 more
TL;DR: An expansion of resident memory T helper 17 (TH17) cells in human periodontitis is demonstrated and this study highlights distinct functions of TH17 cells in oral immunity and inflammation and paves the way to a new targeted therapeutic approach for the treatment ofperiodontitis.
Perlecan regulates pericyte dynamics in the maintenance and repair of the blood-brain barrier.
Kuniyuki Nakamura,Kuniyuki Nakamura,Tomoko Ikeuchi,Kazuki Nara,Kazuki Nara,Craig Rhodes,Peipei Zhang,Yuta Chiba,Saiko Kazuno,Yoshiki Miura,Tetsuro Ago,Eri Arikawa-Hirasawa,Yoh Suke Mukouyama,Yoshihiko Yamada +13 more
TL;DR: An ECM protein, perlecan, maintains BBB integrity and regulates pericyte recruitment after ischemic stroke through the cooperative function of PDGFRβ and integrin α5β1.
T cell exosome–derived miR-142-3p impairs glandular cell function in Sjögren’s syndrome
Juan Cortes-Troncoso,Shyh-Ing Jang,Paola Perez,Jorge Hidalgo,Tomoko Ikeuchi,Teresa Greenwell-Wild,Blake M. Warner,Niki M. Moutsopoulos,Ilias Alevizos +8 more
TL;DR: Evidence is provided for a functional role of the miR-142-3p in SS pathogenesis and the concept that T cell activation may directly impair epithelial cell function through secretion of miRNA-containing exosomes is promoted.
Neutrophil extracellular traps and extracellular histones potentiate IL-17 inflammation in periodontitis.
Tae Sung Kim,Lakmali Munasinghage Silva,Vasileios Ionas Theofilou,Teresa Greenwell-Wild,Lu Li,Tomoko Ikeuchi,Laurie Brenchley,Thomas H. Bugge,Patricia Diaz,Mariana J. Kaplan,Carmelo Carmona-Rivera,Niki M. Moutsopoulos +11 more
TL;DR: In this article , neutrophils infiltrate the gingival oral mucosa at early time points after disease induction and expel extracellular traps (NETs) to trigger mucosal inflammation and bone destruction in vivo.
Identification of peptides derived from the C-terminal domain of fibulin-7 active for endothelial cell adhesion and tube formation disruption.
Susana de Vega,Kentaro Hozumi,Nobuharu Suzuki,Risa Nonaka,Eimi Seo,Anna Takeda,Tomoko Ikeuchi,Motoyoshi Nomizu,Yoshihiko Yamada,Eri Arikawa-Hirasawa +9 more
TL;DR: The results suggest that three peptides from Fbln7‐C are biologically active for endothelial cell adhesion and disrupt the tube formation, suggesting a potential therapeutic use of these peptides for angiogenesis‐related diseases.