Flow chemistry involves the use of channels or tubing to conduct a reaction in a continuous stream rather than in a flask Flow equipment provides chemists with unique control over reaction parameters enhancing reactivity or in some cases enabling new reactions This relatively young technology has received a remarkable amount of attention in the past decade with many reports on what can be done in flow Until recently, however, the question, “Should we do this in flow?” has merely been an afterthought This review introduces readers to the basic principles and fundamentals of flow chemistry and critically discusses recent flow chemistry accounts

The Hitchhiker's Guide to Flow Chemistry

https://rua.ua.es/dspace/bitstream/10045/88608/5/2019_Beletskaya_etal_CoordChemRev_revised.pdf

The Suzuki-Miyaura reaction after the Nobel prize

In science and technology today, the crucial importance of the regulation of nanoscale objects and structures is well recognized. The production of functional material systems using nanoscale units can be achieved via the fusion of nanotechnology with the other research disciplines. This task is a part of the emerging concept of nanoarchitectonics, which is a concept moving beyond the area of nanotechnology. The concept of nanoarchitectonics is supposed to involve the architecting of functional materials using nanoscale units based on the principles of nanotechnology. In this focus article, the essences of nanotechnology and nanoarchitectonics are first explained, together with their historical backgrounds. Then, several examples of material production based on the concept of nanoarchitectonics are introduced via several approaches: (i) from atomic switches to neuromorphic networks; (ii) from atomic nanostructure control to environmental and energy applications; (iii) from interfacial processes to devices; and (iv) from biomolecular assemblies to life science. Finally, perspectives relating to the final goals of the nanoarchitectonics approach are discussed.

Nanoarchitectonics: what's coming next after nanotechnology?

In the last 30 years, C⁻C cross coupling reactions have become a reliable technique in organic synthesis due their versatility and efficiency. While drawbacks have been experienced on an industrial scale with the use of homogenous systems, many attempts have been made to facilitate a heterogeneous renaissance. Thus, this review gives an overview of the current status of the use of heterogeneous catalysts particularly in Suzuki and Heck reactions. Most recent developments focus on palladium immobilised or supported on various classes of supports, thus this review highlights and discuss contributions of the last decade.

https://www.mdpi.com/1420-3049/23/7/1676/pdf

The Current Status of Heterogeneous Palladium Catalysed Heck and Suzuki Cross-Coupling Reactions

While acid fluorides can readily be made from widely available or biomass-feedstock-derived carboxylic acids, their use as functional groups in metal-catalyzed cross-coupling reactions is rare. This report presents the first demonstration of Pd-catalyzed decarbonylative functionalization of acid fluorides to yield trifluoromethyl arenes (ArCF3). The strategy relies on a Pd/Xantphos catalytic system and the supply of fluoride for transmetalation through intramolecular redistribution to the the Pd center. This strategy eliminated the need for exogenous and detrimental fluoride additives and allows Xantphos to be used in catalytic trifluoromethylations for the first time. Our experimental and computational mechanistic data support a sequence in which transmetalation by R3SiCF3 occurs prior to decarbonylation.

https://onlinelibrary.wiley.com/doi/pdf/10.1002/ange.201800644

Palladium‐Catalyzed Decarbonylative Trifluoromethylation of Acid Fluorides

A Lewis-acid-catalyzed method for the substrate-directed formation of peptide bonds has been developed, and this powerful approach is utilized for the new "remote" activation of carboxyl groups under solvent-free conditions. The presented method has the following advantages: (1) the high-yielding peptide synthesis uses a tantalum catalyst for any amino acids; (2) the reaction proceeds without any racemization; (3) the new substrate-directed chemical ligation using the titanium catalyst is applicable to convergent peptide synthesis. These advantages overcome some of the unresolved problems in classical peptide synthesis.

Substrate-Directed Lewis-Acid Catalysis for Peptide Synthesis

An account of the development of Lewis-acid-catalyzed methods for racemization-free peptide synthesis is presented. These methods are based on the substrate control concept that has been exploited ...

Game Change from Reagent- to Substrate-Controlled Peptide Synthesis

The continuous flow Suzuki-Miyaura reaction between various haloarenes and arylboronic acids was successfully achieved within only ca. 20 s during the single-pass through a cartridge filled with palladium on carbon (Pd/C). No palladium leaching was observed in the collected reaction solution by atomic absorption spectrometry (detection limit: 1 ppm).

Palladium on Carbon-Catalyzed Suzuki-Miyaura Coupling Reaction Using an Efficient and Continuous Flow System

Selective Synthesis of Primary Amines from Nitriles under Hydrogenation Conditions

Amide bond formation: beyond the dilemma between activation and racemisation.

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