Tomoaki Takai
Osaka Medical College
42 Papers
76 Citations
Tomoaki Takai is an academic researcher from Osaka Medical College. The author has contributed to research in topics: Medicine & Biology. The author has an hindex of 13, co-authored 35 publications. Previous affiliations of Tomoaki Takai include Brigham and Women's Hospital & Gifu University.
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Papers
Regulated Polarization of Tumor-Associated Macrophages by miR-145 via Colorectal Cancer-Derived Extracellular Vesicles.
Haruka Shinohara,Yuki Kuranaga,Minami Kumazaki,Nobuhiko Sugito,Yuki Yoshikawa,Tomoaki Takai,Kohei Taniguchi,Kohei Taniguchi,Yuko Ito,Yukihiro Akao +9 more
TL;DR: It is suggested that colorectal cancer cells use miR-145 within EVs to efficiently modulate M2-like macrophage polarization and tumor progression.
159
MiR-133b inhibits growth of human gastric cancer cells by silencing pyruvate kinase muscle-splicer polypyrimidine tract-binding protein 1.
Taro Sugiyama,Kohei Taniguchi,Nobuhisa Matsuhashi,Toshihiro Tajirika,Manabu Futamura,Tomoaki Takai,Yukihiro Akao,Kazuhiro Yoshida +7 more
TL;DR: Findings indicated that miR‐133b acted as a tumor‐suppressor through negative regulation of the Warburg effect in gastric cancer cells.
114
MiR-145 negatively regulates Warburg effect by silencing KLF4 and PTBP1 in bladder cancer cells
Koichiro Minami,Kohei Taniguchi,Kohei Taniguchi,Nobuhiko Sugito,Yuki Kuranaga,Teruo Inamoto,Kiyoshi Takahara,Tomoaki Takai,Yuki Yoshikawa,Yuki Yoshikawa,Satoshi Kiyama,Yukihiro Akao,Haruhito Azuma +12 more
TL;DR: MiR-145 perturbed the Warburg effect by suppressing the KLF4/PTBP1/PKMs pathway in BC cells, resulting in significant cell growth inhibition and apoptosis.
Incidence of urethral stricture after bipolar transurethral resection of the prostate using TURis: results from a randomised trial.
Kazumasa Komura,Teruo Inamoto,Tomoaki Takai,Taizo Uchimoto,Kenkichi Saito,Naoki Tanda,Koichiro Minami,Rintaro Oide,Hirofumi Uehara,Kiyoshi Takahara,Hajime Hirano,Hayahito Nomi,Satoshi Kiyama,Toshikazu Watsuji,Haruhito Azuma +14 more
TL;DR: To assess whether bipolar transurethral resection of the prostate (B‐TURP) using the TURis system has a similar level of efficacy and safety to that of the traditional monopolar transure thirdral resections (M‐TurP), and to evaluate the impact of the Turis system on postoperative urethral stricture rates over a 36‐month follow‐up period.
66
CRISPR screens reveal genetic determinants of PARP inhibitor sensitivity and resistance in prostate cancer
Takuya Tsujino,Tomoaki Takai,Kunihiko Hinohara,Fu Gui,Takeshi Tsutsumi,Xiao Bai,Chenkui Miao,Chao Feng,Bin Gui,Zsofia Sztupinszki,Antoine Simoneau,Ning Xie,Ladan Fazli,Xuesen Dong,Haruhito Azuma,Atish D. Choudhury,Kent W. Mouw,Zoltan Szallasi,Lee Zou,Adam S. Kibel,Li Jia +20 more
TL;DR: The authors performed genome-wide CRISPR-Cas9 knockout screens in BRCA1/2-proficient prostate cancer cells and identified previously unknown genes whose loss has a profound impact on PARP inhibitor response.