Tomaz Einfalt
University of Basel
16 Papers
25 Citations
Tomaz Einfalt is an academic researcher from University of Basel. The author has contributed to research in topics: Nanocarriers & Chemistry. The author has an hindex of 6, co-authored 14 publications.
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Papers
Biomimetic artificial organelles with in vitro and in vivo activity triggered by reduction in microenvironment
Tomaz Einfalt,Dominik Witzigmann,Christoph Edlinger,Sandro Sieber,Roland Goers,Roland Goers,Adrian Najer,Mariana Spulber,Ozana Onaca-Fischer,Jörg Huwyler,Cornelia G. Palivan +10 more
TL;DR: These biomimetic AOs are functional in vivo in zebrafish embryos, which demonstrates the feasibility of using AOs as cellular implants in living organisms and opens new perspectives for patient-oriented protein therapy.
Biomimetic Strategy To Reversibly Trigger Functionality of Catalytic Nanocompartments by the Insertion of pH-Responsive Biovalves.
Christoph Edlinger,Tomaz Einfalt,Mariana Spulber,Anja Car,Wolfgang Meier,Cornelia G. Palivan +5 more
TL;DR: This strategy provides straightforward solutions for the development of catalytic nanocompartments efficiently producing desired molecules in a controlled, stimuli-responsive manner with high potential in areas, such as medicine, analytical chemistry, and catalysis.
Active surfaces engineered by immobilizing protein-polymer nanoreactors for selectively detecting sugar alcohols.
Xiaoyan Zhang,Mihai Lomora,Tomaz Einfalt,Wolfgang Meier,Noreen Klein,Dirk Schneider,Cornelia G. Palivan +6 more
TL;DR: The nanoreactors preserved their architecture and activity after immobilization on the glass surface, and represent active biosensing surfaces for selective detection of sugar alcohols, with high sensitivity.
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Live Follow-Up of Enzymatic Reactions Inside the Cavities of Synthetic Giant Unilamellar Vesicles Equipped with Membrane Proteins Mimicking Cell Architecture
TL;DR: This work introduces a functional cell-mimetic compartment formed by insertion of the model biopore bacterial membrane protein OmpF in thick synthetic membranes of an artificial GUV compartment that encloses-as a model-the oxidative enzyme horseradish peroxidase.
Incorporation of phosphatidylserine improves efficiency of lipid based gene delivery systems.
Claudia. Lotter,Claudio L. Alter,Jan Stephan Bolten,Pascal Detampel,Cornelia G. Palivan,Tomaz Einfalt,Jörg Huwyler +6 more
TL;DR: It is demonstrated that PS can be incorporated into non-viral lipid nanoparticle (LNP) pDNA/mRNA constructs to enhance cellular transfection and opens new avenues for efficient gene therapy and can be easily extended to other therapeutic systems.
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