Tomás S. Huerta
The Feinstein Institute for Medical Research
20 Papers
18 Citations
Tomás S. Huerta is an academic researcher from The Feinstein Institute for Medical Research. The author has contributed to research in topics: Medicine & Vagus nerve. The author has an hindex of 7, co-authored 12 publications. Previous affiliations of Tomás S. Huerta include Hofstra University.
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Papers
Lupus antibodies induce behavioral changes mediated by microglia and blocked by ACE inhibitors.
Jacquelyn Nestor,Yoshiyuki Arinuma,Tomás S. Huerta,Tomás S. Huerta,Czeslawa Kowal,Elham Nasiri,Nina Kello,Yuichiro Fujieda,Alison Bialas,Timothy R. Hammond,Uma Sriram,Beth Stevens,Patricio T. Huerta,Patricio T. Huerta,Bruce T. Volpe,Betty Diamond +15 more
TL;DR: It is shown that activated microglia and C1q are critical mediators of neuronal damage and that centrally acting inhibitors of angiotensin-converting enzyme (ACE) can prevent microglial activation and preserve neuronal function and cognitive performance.
Lupus autoantibodies act as positive allosteric modulators at GluN2A-containing NMDA receptors and impair spatial memory.
Kelvin Chan,Jacquelyn Nestor,Jacquelyn Nestor,Tomás S. Huerta,Noele Certain,Gabrielle Moody,Czeslawa Kowal,Patricio T. Huerta,Patricio T. Huerta,Bruce T. Volpe,Betty Diamond,Lonnie P. Wollmuth +11 more
TL;DR: It is found that DNRAb-mediated disruption of spatial memory characterized by early neuronal cell death and subsequent microglia-dependent pathologies requires GluN2A-containing NMDARs.
Stimulation of the hepatoportal nerve plexus with focused ultrasound restores glucose homoeostasis in diabetic mice, rats and swine
Victoria Cotero,John Frederick Graf,Hiromi Miwa,Zall Hirschstein,Khaled Qanud,Tomás S. Huerta,Ningwen Tai,Yuyan Ding,Kevin Jimenez-Cowell,Jacquelyn N. Tomaio,Weiguo Song,Alex Devarajan,Tea Tsaava,Radhika Madhavan,Kirk D. Wallace,Evelina Roxana Loghin,Christine A. Morton,Ying Fan,Tzu-Jen Kao,Kainat Akhtar,Meghana Damaraju,Linda Barenboim,Teresa Maietta,Jeffrey Michael Ashe,Kevin J. Tracey,Thomas Coleman,Dino Di Carlo,Damian S. Shin,Stavros Zanos,Sangeeta S. Chavan,Raimund I. Herzog,Christopher Michael Puleo +31 more
TL;DR: It is shown that the selective activation of the nerve plexus of the hepatic portal system via peripheral focused ultrasound stimulation improves glucose homoeostasis in mice and rats with insulin-resistant diabetes and in swine subject to hyperinsulinemic-euglycaemic clamps.
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Preclinical Models of Overwhelming Sepsis Implicate the Neural System that Encodes Contextual Fear Memory
Patricio T. Huerta,Patricio T. Huerta,Sergio Robbiati,Tomás S. Huerta,Anchal Sabharwal,Rose Ann Berlin,Maya Frankfurt,Bruce T. Volpe,Bruce T. Volpe +8 more
TL;DR: It is shown that contextual fear conditioning, a form of associative memory for fear, is chronically disrupted in CLP mice when compared with sham-operated animals, and structural damage in the amygdalar-hippocampal network represents the neural substrate for impaired contextual fear memory in long-term sepsis survivors.
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Targeted peripheral focused ultrasound stimulation attenuates obesity-induced metabolic and inflammatory dysfunctions.
Tomás S. Huerta,Tomás S. Huerta,Alex Devarajan,Tea Tsaava,Arvind Rishi,Victoria Cotero,Christopher Michael Puleo,Jeffrey Michael Ashe,Thomas Coleman,Eric H. Chang,Eric H. Chang,Kevin J. Tracey,Kevin J. Tracey,Sangeeta S. Chavan,Sangeeta S. Chavan +14 more
TL;DR: In this article, the liver-focused ultrasound stimulation of the liver may alleviate obesity-related inflammation and other comorbidities, which is associated with an increased risk of morbidity and mortality.
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