Tomas Blom
University of Helsinki
29 Papers
271 Citations
Tomas Blom is an academic researcher from University of Helsinki. The author has contributed to research in topics: Sphingosine & Sphingolipid. The author has an hindex of 16, co-authored 27 publications. Previous affiliations of Tomas Blom include Åbo Akademi University & Minerva Foundation Institute for Medical Research.
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Papers
Batten disease (JNCL) is linked to disturbances in mitochondrial, cytoskeletal, and synaptic compartments.
Kaisu Luiro,Outi Kopra,Tomas Blom,Massimiliano Gentile,Hannah M. Mitchison,Iiris Hovatta,Kid Törnquist,Anu Jalanko +7 more
TL;DR: In this article, a comparative global transcript profiling of the embryonic, primary cultures of the Cln3-/- mouse neurons was carried out, and functional analyses delineated three major cellular pathways or compartments affected: mitochondrial glucose metabolism, cytoskeleton, and synaptosome.
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NDRG1 functions in LDL receptor trafficking by regulating endosomal recycling and degradation.
Vilja Pietiäinen,Boris Vassilev,Boris Vassilev,Tomas Blom,Tomas Blom,Wei Wang,Wei Wang,Jessica K. Nelson,Robert Bittman,Nils Bäck,Noam Zelcer,Elina Ikonen,Elina Ikonen +12 more
TL;DR: It is reported that NDRG1 silencing in epithelial cells results in decreased uptake of low-density lipoprotein (LDL) due to reduced LDL receptor (LDLR) abundance at the plasma membrane, and co-depletion of IDOL, which ubiquitylates the LDLR and promotes its degradation, rescues plasma membrane LDLR levels and LDL uptake.
LAPTM4B facilitates late endosomal ceramide export to control cell death pathways
Tomas Blom,Tomas Blom,Shiqian Li,Shiqian Li,Andrea Dichlberger,Andrea Dichlberger,Nils Bäck,Young Ah Kim,Ursula Loizides-Mangold,Howard Riezman,Robert Bittman,Elina Ikonen,Elina Ikonen +12 more
TL;DR: Novel ceramide probes are used to provide evidence that LAPTM4B interacts with ceramide and facilitates its removal from late endosomal organelles (LEs) and uncover a cellular ceramide export route from LEs and identify LAP TM4B as its regulator.
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FTY720 Stimulates 27-Hydroxycholesterol Production and Confers Atheroprotective Effects in Human Primary Macrophages
Tomas Blom,Nils Bäck,Aino-Liisa Mutka,Robert Bittman,Zaiguo Li,Angel R. de Lera,Petri T. Kovanen,Ulf Diczfalusy,Elina Ikonen +8 more
TL;DR: FTY720 decreases cholesterol toxicity in primary human macrophages by reducing the delivery of scavenged lipoprotein cholesterol to the endoplasmic reticulum and facilitating its release to physiological extracellular acceptors and identifying a novel mechanism by which FTY720 modulates signaling.
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