Tom Strachan
University of Newcastle
8 Papers
133 Citations
Tom Strachan is an academic researcher from University of Newcastle. The author has contributed to research in topics: Embryonic stem cell & Gene. The author has an hindex of 8, co-authored 8 publications. Previous affiliations of Tom Strachan include Centre for Life & Newcastle University.
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Papers
3 dimensional modelling of early human brain development using optical projection tomography
Janet Kerwin,Mark Scott,James Sharpe,Luis Puelles,Stephen C. Robson,Margaret Martínez-de-la-Torre,José Luis Ferran,Guangjie Feng,Richard Baldock,Tom Strachan,Duncan Davidson,Susan Lindsay +11 more
TL;DR: In the CS17 model considerable detail is visible within the developing nervous system at a minimum resolution of ~20 μm and 3D anatomical and gene expression domains can be defined and visualised successfully.
Cornelia de Lange Syndrome and the link between chromosomal function, DNA repair and developmental gene regulation
TL;DR: CdLS is likely to be one of several developmental disorders resulting from defective expression of a multi-functional protein with roles in chromosome function, gene regulation and double-strand DNA repair - a combination of properties shared by certain bacterial proteins responsible for structural maintenance of chromatin.
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3D modelling, gene expression mapping and post-mapping image analysis in the developing human brain.
Subrot Sarma,Janet Kerwin,Luis Puelles,Mark Scott,Tom Strachan,Guangjie Feng,James Sharpe,Duncan Davidson,Richard Baldock,Susan Lindsay +9 more
TL;DR: Three-dimensional models are generated and used to compare forebrain development at two embryonic stages and as a means of recording, storing and visualising gene expression data for three example genes EMX1, EMX2 and OTX2.
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Silencing of the expression of pluripotent driven-reporter genes stably transfected into human pluripotent cells
Rebecca Stewart,Chunbo Yang,George Anyfantis,Stefan Przyborski,Stefan Przyborski,Nicholas Hole,Nicholas Hole,Tom Strachan,Miodrag Stojkovic,WN Keith,Lyle Armstrong,Majlinda Lako +11 more
TL;DR: The data suggest that human ES and EC cells are able to silence pluripotent promoter-driven reporter genes with high efficiency and need to be investigated before large-scale comparative reporter-based transfections can be used as a tool in human embryonic stem cell biology.
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Metazoan Scc4 homologs link sister chromatid cohesion to cell and axon migration guidance
Vlad C. Seitan,Peter Banks,Steve Laval,Nazia Abdul Majid,Dale Dorsett,Amer Ahmed Rana,James C. Smith,Alex Bateman,Sanja Krpic,Arnd Hostert,Robert A. Rollins,Hediye Erdjument-Bromage,Paul Tempst,Claire Y. Bénard,Siegfried Hekimi,Sarah F. Newbury,Tom Strachan +16 more
TL;DR: The data show that sister chromatid cohesion in metazoans involves the formation of a complex similar to the Scc2-Scc4 interaction in the budding yeast, consistent with increased selection pressure to conserve additional essential functions, such as regulation of cell and axon migration during development.