8 Papers
18 Citations
Tom Nebl is an academic researcher from Commonwealth Scientific and Industrial Research Organisation. The author has contributed to research in topics: Cancer & Protein Data Bank. The author has an hindex of 3, co-authored 8 publications.
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Papers
Crystal structures of human ENPP1 in apo and bound forms.
Matthew L. Dennis,Janet Newman,Olan Dolezal,Meghan Hattarki,Regina Surjadi,Stewart D. Nuttall,Tam Pham,Tom Nebl,Michelle Ang Camerino,Poh Sim Khoo,Brendon J. Monahan,Thomas S. Peat +11 more
- 01 Sep 2020
TL;DR: Structures of the cancer target human ENPP1 have been determined in the apo form, bound to nucleotides and bound to known inhibitors of the enzyme.
The Glitazone Class of Drugs as Carbonic Anhydrase Inhibitors-A Spin-Off Discovery from Fragment Screening.
Sarah L Mueller,Panagiotis K. Chrysanthopoulos,Maria A. Halili,Caryn Hepburn,Tom Nebl,Claudiu T. Supuran,Alessio Nocentini,Thomas S. Peat,Sally-Ann Poulsen +8 more
TL;DR: In this article, three glitazone drugs (troglitazone 11, rosiglitaxone 12 and pioglitazones 13) were investigated and characterised for binding to carbonic anhydrases (CA, EC 4.2.1) using native mass spectrometry, protein X-ray crystallography, and hydrogen-deuterium exchange (HDX) mass-spectrometry.
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Structures of the transcriptional regulator BgaR, a lactose sensor.
Janet Newman,Karine Caron,Tom Nebl,Thomas S. Peat +3 more
- 01 Jul 2019
TL;DR: The structure of BgaR, a transcriptional regulator of the lactose operon in Clostridium perfringens, has been solved by SAD phasing using a mercury derivative as mentioned in this paper.
The X-ray crystal structure of the N-terminal domain of Ssr4, a Schizosaccharomyces pombe chromatin-remodelling protein
TL;DR: The N-terminal domain of Ssr4 from S. pombe, which is an integral protein in the SWI/SNF and RSC chromatin-remodelling complexes, has been crystallized and its structure has been solved using iodine as a phasing vehicle.
Engineered Enzymes that Retain and Regenerate their Cofactors Enable Continuous-Flow Biocatalysis
Carol J. Hartley,Charlotte C. Williams,Judith A. Scoble,Quentin I. Churches,Andrea North,Nigel G. French,Tom Nebl,Greg Coia,Andrew C. Warden,Greg Simpson,Andrew R. Frazer,Chantel N. Jensen,Nicholas J. Turner,Colin Scott +13 more
TL;DR: This data indicates that N6-2AE-ADP can be synthesised using the G3PDEc-NOXCa-Est2Aa-FruASc-Est 2Aa method, and the expression of individual enzymes and protein expression can be controlled by fusions between these two methods.