Tom L. Blundell
University of Cambridge
716 Papers
8.7K Citations
Tom L. Blundell is an academic researcher from University of Cambridge. The author has contributed to research in topics: Protein structure & Biology. The author has an hindex of 86, co-authored 687 publications. Previous affiliations of Tom L. Blundell include Agricultural and Food Research Council & University of Oxford.
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Papers
Protein three-dimensional structural databases: domains, structurally aligned homologues and superfamilies
Ramanathan Sowdhamini,David F. Burke,Charlotte M. Deane,Jing-fei Huang,Jing-fei Huang,Kenji Mizuguchi,Hampapathulu A. Nagarajaram,John P. Overington,Narayanaswamy Srinivasan,Robert E. Steward,Tom L. Blundell +10 more
TL;DR: Information in the database of protein structural domains, an alignment database of homologous proteins (HOMSTRAD), and a database of structurally aligned superfamilies on the WWW should be of value to crystallographers in the comparison of newly determined protein structures with previously identified protein domains or existing families.
Threonine 57 is required for the post-translational activation of Escherichia coli aspartate α-decarboxylase.
Michael E. Webb,Briony A. Yorke,Tom Kershaw,Sarah L. Lovelock,C.M.C. Lobley,Mairi L. Kilkenny,Alison G. Smith,Tom L. Blundell,Arwen R. Pearson,Chris Abell +9 more
TL;DR: The crystal structure of the site-directed mutant T57V is reported and threonine 57 is identified as the key residue required for the post-translational activation of E. coli aspartate decarboxylase.
Arabesque: a tool for protein structural comparison using differential geometry and knot theory
Hoi Tik,Alvin Leung,Bernardo Ochoa Montano,Tom L. Blundell,Michele Vendruscolo,Rinaldo W. Montalvao +5 more
- 01 Jan 2012
TL;DR: ARABESQUE as discussed by the authors is a new tool for protein structure analysis, which includes structure comparison, generation of annotated structural alignments, and annotated superposition of structures.
Fragment-based drug discovery in academia: Experiences from a tuberculosis programme
Timo J. Heikkila,Sachin Surade,Hernani Leonardo Silvestre,Marcio Vinicius Bertacine Dias,Alessio Ciulli,Karen M. Bromfield,Duncan Scott,Nigel I. Howard,Shijun Wen,Alvin Hung Wei,David Osborne,Chris Abell,Tom L. Blundell +12 more
- 01 Jan 2009
TL;DR: In this review, the suitability of fragment-based methods for developing new chemotherapeutics against neglected diseases are discussed, providing examples from the authors' tuberculosis programme.
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Domain structure of hepatocyte growth factor/scatter factor (HGF/SF).
Ermanno Gherardi,Guido Hartmann,Jonathan Hepple,Dimitri Y. Chirgadze,Narayanaswamy Srinivasan,Tom L. Blundell +5 more
- 01 Jan 1997
TL;DR: The modular structure of hepatocyte growth factor/scatter factor (HGF/SF) has facilitated structure-function analysis as mentioned in this paper, and the 3D structures of the six domains of HGF were modelled on the structure of homologues, offering interesting insights into putative mechanisms of domain interactions, receptor binding and activation.
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