Tom L. Blundell
University of Cambridge
716 Papers
8.7K Citations
Tom L. Blundell is an academic researcher from University of Cambridge. The author has contributed to research in topics: Protein structure & Biology. The author has an hindex of 86, co-authored 687 publications. Previous affiliations of Tom L. Blundell include Agricultural and Food Research Council & University of Oxford.
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Papers
TIBLE: a web-based, freely accessible resource for small-molecule binding data for mycobacterial species.
TL;DR: The resource integrates disparate public data and methods to provide easy access to the minimum inhibitory concentration and binding data, facilitation of data sharing, and identification of small molecules and targets for development of anti-tuberculosis therapeutics.
A monomeric insulin from the casiragua: molecular model building using computer graphics.
Tom L. Blundell,Richard Horuk +1 more
TL;DR: Three-dimensional computer graphics have been used to construct a three-dimensional model of casiragua insulin assuming a tertiary structural homology with that of porcine insulin, finding that the hydrophobic core of the molecule is conserved, but theHydrophobic surfaces involved in formation of dimers and hexamers in porCine insulin are more hydrophilic and contain charged residues.
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Patterns of sequence variation in families of homologous proteins
Tom L. Blundell,Jon B. Cooper,Dan Donnelly,Huub P. C. Driessen,Yvonne J. K. Edwards,Frank Eisenmenger,Carlos Frazao,Mark S. Johnson,Karsten Niefind,Matthew Newman,John P. Overington,Andrej Sali,Christine Slingsby,V. Nalini,Zhan-Yang Zhu +14 more
- 01 Jan 1991
TL;DR: Residue to residue substitution tables have been calculated for amino acids classified according to residue type, secondary structure, accessibility of the sidechain, and existence of hydrogen bonds from sidechain to other sidechains or peptide carbonyl or amide functions.
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Crystallisation and preliminary crystallographic data of a porcine neurophysin I-Tyr-Phe-NH2 complex.
James E. Pitts,S.P. Wood,Leslie Hearn,Ian J. Tickle,C.-W. Wu,Tom L. Blundell,I.C.A.F. Robinson +6 more
TL;DR: The structure analysis of neurophysin bound to a hormone peptide analogue should contribute to the understanding of many biochemical questions and might provide a rare opportunity to define neurophysins.
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