7 Papers
41 Citations
Todd Rigney is an academic researcher from University of Texas Health Science Center at Houston. The author has contributed to research in topics: Porphyromonas gingivalis & Gene. The author has an hindex of 7, co-authored 7 publications. Previous affiliations of Todd Rigney include University of Texas Dental Branch at Houston & University of Texas at Austin.
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Papers
Natural Competence Is a Major Mechanism for Horizontal DNA Transfer in the Oral Pathogen Porphyromonas gingivalis
Gena D. Tribble,Todd Rigney,Doan Hieu V Dao,Cindy T. Wong,Jennifer E. Kerr,Brendan E. Taylor,Sara Pacha,Heidi B. Kaplan +7 more
TL;DR: The role of putative DNA transfer genes in conjugation and transformation is examined and it is demonstrated that natural competence mediated by comF is the dominant form of chromosomal DNA transfer, with transfer by a conjugated-like mechanism playing a minor role.
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Porphyromonas gingivalis infection increases osteoclastic bone resorption and osteoblastic bone formation in a periodontitis mouse model.
TL;DR: Although P. gingivalis appears to suppress osteoblast pool and enhance osteoclastic bone resorption, the bone formation capacity is temporarily elevated in the infected mice, possibly via some anti-microbial compensational mechanisms.
Fimbriae of Porphyromonas gingivalis are important for initial invasion of osteoblasts, but not for inhibition of their differentiation and mineralization.
TL;DR: It is revealed that major fimbriae are involved in the initial invasion of osteoblasts by P. gingivalis, but are not essential for the subsequent inhibition of osteoblast differentiation and mineralization in long-term culture.
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Genetic Analysis of Mobile tetQ Elements in Oral Prevotella Species
Gena D. Tribble,John J. Garza,Victor L. Yeung,Todd Rigney,Doan Hieu V Dao,Paulo Henrique Mazza Rodrigues,Clay Walker,C J Smith +7 more
TL;DR: The genetic analysis of mobile tetQ elements in oral Prevotella species indicates that the mobile elements encoding tetQ in oral species are distinct from those found in the Bacteroides.
20
Genetic exchange of fimbrial alleles exemplifies the adaptive virulence strategy of Porphyromonas gingivalis.
Jennifer E. Kerr,Jared R. Abramian,Doan Hieu V Dao,Todd Rigney,Jamie Fritz,Tan Pham,Kavitha Parthasarathy,Bing-Yan Wang,Wenjian Zhang,Gena D. Tribble +9 more
TL;DR: This is the first study to quantitatively assess the adaptive effect of exchanging genes within the pan genome cloud, and presents a potential mechanism by which opportunistic pathogens may acquire the traits necessary to modify host-microbial interactions.