A bioerodible endoprosthesis erodes by galvanic erosion that can provide, e.g., improved endothelialization and therapeutic effects.

Bioerodible endoprostheses and methods of making the same

The present invention comprises a medical device having an underlying structure on which is disposed a fiber meshwork composed of one or more fibers of substantially uniform diameter. The fiber meshwork may optionally have a multi-layer structure disposed upon it. Either or both of the fiber meshwork or the multi-layer structure may have one or more therapeutic agents absorbed within it. The fiber meshwork is permeable to body fluids and thereby permits body fluids to contact the underlying structure to facilitate its controlled disintegration. The fiber meshwork degrades more slowly than the underlying structure thereby permitting release of the therapeutic agent over a timescale longer than that of the lifetime of the underlying structure, while also ensuring that the support function of the underlying structure is not abrogated by the disintegration of the underlying structure.

Endoprosthesis having a fiber meshwork disposed thereon

Medical devices such as endoprostheses (e.g., stents) containing one or more biostable layers (e.g., biostable inorganic layers) and a biodegradable underlying structure are disclosed.

Bioerodible endoprosthesis with biostable inorganic layers

A bioerodible endoprosthesis erodes to a desirable geometry that can provide, e.g., improved mechanical properties or degradation characteristics.

The present invention comprises a medical device (10) having a support structure (4) made from alternating layers.

Endoprosthesis with three-dimensional disintegration control

An endoprothesis (208) comprising a bioerodible body having local erosion rates of the body that vary as a continuous function of radial distance (d) from the longitudinal axis (212).

Controlling biodegradation of a medical instrument

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Controlling biodegradation of a medical instrument