Todd D. Gould
University of Maryland, Baltimore
142 Papers
372 Citations
Todd D. Gould is an academic researcher from University of Maryland, Baltimore. The author has contributed to research in topics: Lithium (medication) & Medicine. The author has an hindex of 52, co-authored 124 publications. Previous affiliations of Todd D. Gould include University of Maryland, College Park & Johns Hopkins University.
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Papers
The Endophenotype Concept in Psychiatry: Etymology and Strategic Intentions
TL;DR: The authors discuss the etymology and strategy behind the use of endophenotypes in neuropsychiatric research and, more generally, in research on other diseases with complex genetics.
NMDAR inhibition-independent antidepressant actions of ketamine metabolites
Panos Zanos,Ruin Moaddel,Patrick J. Morris,Polymnia Georgiou,Jonathan Fischell,Greg I. Elmer,Manickavasagom Alkondon,Peixiong Yuan,Heather J. Pribut,Nagendra Singh,Katina Sourou Sylvestre Dossou,Yuhong Fang,Xi Ping Huang,Cheryl L. Mayo,Irving W. Wainer,Edson X. Albuquerque,Scott M. Thompson,Craig J. Thomas,Carlos A. Zarate,Todd D. Gould +19 more
TL;DR: It is shown that the metabolism of (R,S)-ketamine to (2S,6S;2R,6R)-hydroxynorketamine (HNK) is essential for its antidepressant effects, and that the HNK enantiomer exerts behavioural, electroencephalographic, electrophysiological and cellular antidepressant-related actions in mice.
Ketamine and Ketamine Metabolite Pharmacology: Insights into Therapeutic Mechanisms
Panos Zanos,Ruin Moaddel,Patrick J. Morris,Lace M. Riggs,Jaclyn N. Highland,Polymnia Georgiou,Edna F. R. Pereira,Edson X. Albuquerque,Craig J. Thomas,Carlos A. Zarate,Todd D. Gould +10 more
TL;DR: Pharmacological target deconvolution of ketamine and its metabolites will provide insight critical to the development of new pharmacotherapies that possess the desirable clinical effects of ketamines, but limit undesirable side effects.
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Mechanisms of ketamine action as an antidepressant.
Panos Zanos,Todd D. Gould +1 more
TL;DR: In this article, the mechanism of action of ketamine as an antidepressant, including synaptic or GluN2B-selective extra-synaptic N-methyl-D-aspartate receptor (NMDAR) inhibition, localized on GABAergic interneurons, inhibition of NMDAR-dependent burst firing of lateral habenula neurons, and the role of α-amino-3-hydroxy-5methyl-4-isoxazole-propionic acid receptor activation.
The mouse forced swim test.
Adem Can,David T. Dao,Michal Arad,Chantelle E. Terrillion,Sean C. Piantadosi,Todd D. Gould,Todd D. Gould +6 more
TL;DR: This work explains how to conduct the mouse version of this test with emphasis on potential pitfalls that may be detrimental to interpretation of results and how to avoid them and explains how the behaviors manifested in the test are assessed.
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