Tod Steinfeld
16 Papers
105 Citations
Tod Steinfeld is an academic researcher. The author has contributed to research in topics: Agonist & Muscarinic acetylcholine receptor. The author has an hindex of 12, co-authored 16 publications.
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Papers
Carbazole-containing sulfonamides and sulfamides: Discovery of cryptochrome modulators as antidiabetic agents
Paul S. Humphries,Ross Bersot,John F. Kincaid,Eric Mabery,Kerryn McCluskie,Timothy Park,Travis Renner,Erin Riegler,Tod Steinfeld,Eric Douglas Turtle,Zhi-Liang Wei,Erik Willis +11 more
TL;DR: A series of novel carbazole-containing sulfonamides and sulfamides were synthesized, which led to the identification of potent cryptochrome modulators and compound 41 was selected for further profiling.
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Carbazole-containing amides and ureas: Discovery of cryptochrome modulators as antihyperglycemic agents.
Paul S. Humphries,Ross Bersot,John F. Kincaid,Eric Mabery,Kerryn McCluskie,Timothy Park,Travis Renner,Erin Riegler,Tod Steinfeld,Eric Douglas Turtle,Zhi-Liang Wei,Erik Willis +11 more
TL;DR: A series of novel carbazole-containing amides and ureas led to the identification of potent cryptochrome modulators and compound 50 was selected for further profiling on the desired pharmacokinetic/pharmacodynamic parameters.
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Discovery of (R)-1-(3-((2-chloro-4-(((2-hydroxy-2-(8-hydroxy-2-oxo-1,2-dihydroquinolin-5-yl)ethyl)amino)methyl)-5-methoxyphenyl)amino)-3-oxopropyl)piperidin-4-yl [1,1'-biphenyl]-2-ylcarbamate (TD-5959, GSK961081, batefenterol): first-in-class dual pharmacology multivalent muscarinic antagonist and β₂ agonist (MABA) for the treatment of chronic obstructive pulmonary disease (COPD).
Adam D. Hughes,Yan Chen,Sharath S. Hegde,Jeffrey R. Jasper,Sarah Jaw-Tsai,Tae-Weon Lee,Alexander McNamara,M. Teresa Pulido-Rios,Tod Steinfeld,Mathai Mammen +9 more
TL;DR: Batefenterol produced statistical and clinically significant differences compared to placebo and numerically greater improvements in the primary end point of trough FEV1 compared to salmeterol after 4 weeks of dosing in patients with moderate to severe chronic obstructive pulmonary disease (COPD).
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Multivalent dual pharmacology muscarinic antagonist and β₂ agonist (MABA) molecules for the treatment of COPD.
TL;DR: This review focuses on the multivalent origins of dual pharmacology MABA bronchodilators and describes the supporting in vitro characterization and reported animal studies.
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Muscarinic receptor subtypes and signalling involved in the attenuation of isoprenaline-induced rat urinary bladder relaxation
Lambertus P. W. Witte,Noach de Haas,Mathai Mammen,Eric L. Stangeland,Tod Steinfeld,Jayashree Aiyar,Martin C. Michel,Martin C. Michel +7 more
TL;DR: It is concluded that both M2 and M3 receptors contribute to attenuation of β-adrenoceptor-mediated relaxation of rat urinary bladder; the signal transduction pathway involved in the M3 component of this attenuation differs from that mediating direct contractile effects of M3 receptor.