Tobi Van den Bossche
University of Antwerp
19 Papers
60 Citations
Tobi Van den Bossche is an academic researcher from University of Antwerp. The author has contributed to research in topics: Dementia & Frontotemporal lobar degeneration. The author has an hindex of 13, co-authored 16 publications.
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Papers
Association of short-term cognitive decline and MCI-to-AD dementia conversion with CSF, MRI, amyloid- and 18F-FDG-PET imaging.
Julie Ottoy,Ellis Niemantsverdriet,Jeroen Verhaeghe,Ellen De Roeck,Hanne Struyfs,Charisse Somers,Leonie Wyffels,Sarah Ceyssens,Sara Van Mossevelde,Tobi Van den Bossche,Christine Van Broeckhoven,Annemie Ribbens,Maria Bjerke,Sigrid Stroobants,Sebastiaan Engelborghs,Steven Staelens +15 more
TL;DR: Neither amyloid-PET nor CSF biomarkers could discriminate short-term converters from non-converters, and patients with MCI converted to AD dementia at an annual rate of 31%, which could be best predicted by combining neuropsychological testing with either MRI-based HV or 18F-FDG-PET.
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An intronic VNTR affects splicing of ABCA7 and increases risk of Alzheimer's disease.
Arne De Roeck,Lena Duchateau,Jasper Van Dongen,Rita Cacace,Maria Bjerke,Tobi Van den Bossche,Patrick Cras,Rik Vandenberghe,Peter Paul De Deyn,Sebastiaan Engelborghs,Christine Van Broeckhoven,Kristel Sleegers +11 more
TL;DR: T tandem repetitive regions in ABCA7 are investigated in a Belgian cohort of 1529 AD patients and control individuals and an intronic variable number tandem repeat (VNTR) is identified and a tight correlation between exon 19 skipping and VNTR length is observed.
Validation of the Semiquantitative Static SUVR Method for 18F-AV45 PET by Pharmacokinetic Modeling with an Arterial Input Function.
Julie Ottoy,Jeroen Verhaeghe,Ellis Niemantsverdriet,Leonie Wyffels,Charisse Somers,Ellen Elisa De Roeck,Ellen Elisa De Roeck,Hanne Struyfs,Femke Soetewey,Steven Deleye,Tobi Van den Bossche,Sara Van Mossevelde,Sarah Ceyssens,Jan Versijpt,Sigrid Stroobants,Sebastiaan Engelborghs,Steven Staelens +16 more
TL;DR: Increased brain uptake of 18F-AV45 assessed by the simplified static SUVR protocol does not truly reflect Aβ load, but SUVRWM is better correlated with VT and more closely reflects VT differences between aMCI and AD than SUVRCB.
Phenotypic characteristics of Alzheimer patients carrying an ABCA7 mutation.
Tobi Van den Bossche,Kristel Sleegers,Kristel Sleegers,Elise Cuyvers,Elise Cuyvers,Sebastiaan Engelborghs,Anne Sieben,Arne De Roeck,Arne De Roeck,Caroline Van Cauwenberghe,Caroline Van Cauwenberghe,Steven Vermeulen,Steven Vermeulen,Marleen Van den Broeck,Marleen Van den Broeck,Annelies Laureys,Annelies Laureys,Karin Peeters,Karin Peeters,Maria Mattheijssens,Maria Mattheijssens,Mathieu Vandenbulcke,Rik Vandenberghe,Jean-Jacques Martin,Peter Paul De Deyn,Patrick Cras,Christine Van Broeckhoven,Christine Van Broeckhoven +27 more
TL;DR: All patients carrying a loss-of-function mutation in ABCA7 exhibited a classical Alzheimer disease phenotype, though with a striking wide onset age range, suggesting the influence of unknown modifying factors.
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Genetic screening in early-onset dementia patients with unclear phenotype: relevance for clinical diagnosis.
Federica Perrone,Rita Cacace,Sara Van Mossevelde,Tobi Van den Bossche,Peter Paul De Deyn,Patrick Cras,Sebastiaan Engelborghs,Julie van der Zee,Christine Van Broeckhoven +8 more
TL;DR: Overall, this study underscores the relevance of genetic testing of known causal genes in early-onset patients with symptomatology of neurodegenerative dementia but an unclear clinical diagnosis as well as a better understanding of the presence of multiple affected relatives in the family.
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