Tinghan Yang
Sichuan University
34 Papers
49 Citations
Tinghan Yang is an academic researcher from Sichuan University. The author has contributed to research in topics: Medicine & Colorectal cancer. The author has an hindex of 7, co-authored 19 publications.
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Papers
Malignant ascites-derived exosomes promote proliferation and induce carcinoma-associated fibroblasts transition in peritoneal mesothelial cells.
Mingtian Wei,Tinghan Yang,Xiangzheng Chen,Yangping Wu,Xiangbing Deng,Wanbin He,Jinliang Yang,Ziqiang Wang +7 more
TL;DR: Peritoneal MCs showed increased ability to proliferate and migrate under the treatment of ascites-derived exosomes, and expression of CAFs specific proteins markers in MCs, including fibroblast activation protein (FAP), alpha-smooth muscle actin (α-SMA), and fibronectin, were increased after treatment of exosome.
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Isoliquiritigenin prevents the progression of psoriasis-like symptoms by inhibiting NF-κB and proinflammatory cytokines
Yangping Wu,Xiangzheng Chen,Xiaojun Ge,Hongwei Xia,Yuxi Wang,Siyuan Su,Wenting Li,Tinghan Yang,Mingtian Wei,Hang Zhang,Lantu Gou,Jiong Li,Xian Jiang,Jinliang Yang +13 more
TL;DR: ISL exhibited anti-inflammatory effects in psoriasis models, by downregulating IL-6 and IL-8 via suppression of NF-κB activity, suggesting that ISL might serve as a potential candidate for treatment of Psoriasis and other autoimmune inflammatory diseases.
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Peroral Esophageal Myotomy Versus Laparoscopic Heller's Myotomy for Achalasia: A Meta-analysis
TL;DR: POEM achieves equivalent short-term outcomes compared with laparoscopic Heller's myotomy for achalasia, suggesting this novel procedure is a promising treatment for a Chalchasia.
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Targeting of DDR1 with antibody-drug conjugates has antitumor effects in a mouse model of colon carcinoma.
Yiran Tao,Ruixue Wang,Qinhuai Lai,Mengdan Wu,Yuxi Wang,Xiaohua Jiang,Lishi Zeng,Shijie Zhou,Zhongping Li,Tinghan Yang,Yuqin Yao,Yangping Wu,Lin Yu,Yuyin Fu,Weirong Lai,Yujia Peng,Ying Lu,Zhixiong Zhang,Cuiyu Guo,Guangbing Zhang,Lantu Gou,Jinliang Yang +21 more
TL;DR: T4H11‐DM4, an ADC targeting DDR1 which carries the tubulin inhibitor payload DM4, highlights the potential of DDR1‐targeted ADC and may facilitate the development of a new effective therapeutic strategy for colon cancer.
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•Journal Article
A novel 5T4-targeting antibody-drug conjugate H6-DM4 exhibits potent therapeutic efficacy in gastrointestinal tumor xenograft models.
Ruixue Wang,Qinhuai Lai,Liangze Tang,Yiran Tao,Yuqin Yao,Yu Liu,Ying Lu,Chaoyong Shen,Ran Lu,Chuanwen Fan,Ruirui Zhang,Yuxi Wang,Lin Yu,Tinghan Yang,Yangping Wu,Yujia Peng,Xian Wei,Xian Wei,Yuyin Fu,Weirong Lai,Lantu Gou,Jinliang Yang +21 more
TL;DR: In this article, the authors developed a novel anti-5T4 monoclonal antibody with high affinity and robust internalization ability and conjugated it to the potent microtubule inhibitor DM4 to produce conjugate H6-DM4.
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