Timothy M. Tucey
Monash University, Clayton campus
20 Papers
108 Citations
Timothy M. Tucey is an academic researcher from Monash University, Clayton campus. The author has contributed to research in topics: Protein subunit & Telomere. The author has an hindex of 12, co-authored 20 publications. Previous affiliations of Timothy M. Tucey include Brown University & Harvard University.
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Papers
Glucose Homeostasis Is Important for Immune Cell Viability during Candida Challenge and Host Survival of Systemic Fungal Infection
Timothy M. Tucey,Jiyoti Verma,Paul Harrison,Sarah L. Snelgrove,Tricia L. Lo,Allison K. Scherer,Adele Barugahare,David R. Powell,Robert T. Wheeler,Michael J. Hickey,Traude H. Beilharz,Thomas Naderer,Ana Traven +12 more
TL;DR: It is shown that Candida infection perturbs host glucose homeostasis in the murine candidemia model and that glucose supplementation improves host outcomes, supporting the importance of maintaining glucoseHomeostasis for immune cell survival during Candida challenge and for host survival in systemic infection.
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C. elegans notch signaling regulates adult chemosensory response and larval molting quiescence
Komudi Singh,Michael Y. Chao,Gerard A. Somers,Hidetoshi Komatsu,Mark E. Corkins,Jonah Larkins-Ford,Timothy M. Tucey,Heather Dionne,Melissa B. Walsh,Emma Beaumont,Emma Beaumont,Douglas P. Hart,Shawn R. Lockery,Anne C. Hart +13 more
TL;DR: It is reported that Notch ligands, coligands, and the receptors LIN-12 and GLP-1 regulate two C. elegans behaviors: chemosensory avoidance of octanol and quiescence during molting lethargus and genetic epistasis studies reveal that notch signaling regulates quiescent via previously identified circuits and genetic pathways including the egl-4 cGMP-dependent kinase.
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Phylogenetic analysis identifies many uncharacterized actin-like proteins (Alps) in bacteria: regulated polymerization, dynamic instability and treadmilling in Alp7A.
Alan I. Derman,Eric C. Becker,Bao D. Truong,Akina Fujioka,Timothy M. Tucey,Marcella L. Erb,Paula C. Patterson,Joe Pogliano +7 more
TL;DR: A phylogenetic search is conducted and it is suggested that most if not all of the Alps are indeed actin relatives, and that actin is very well represented in bacteria.
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C. elegans lifespan extension by osmotic stress requires FUdR, base excision repair, FOXO, and sirtuins
Edward N. Anderson,Mark E. Corkins,Jia Cheng Li,Komudi Singh,Sadé Parsons,Timothy M. Tucey,Altar Sorkaç,Huiyan Huang,Maria Dimitriadi,David A. Sinclair,Anne C. Hart +10 more
TL;DR: Results demonstrate that FUdR, through inhibition of TYMS-1, activates stress response pathways in somatic tissues to confer hormetic resistance to acute and chronic stress.
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The Endoplasmic Reticulum-Mitochondrion Tether ERMES Orchestrates Fungal Immune Evasion, Illuminating Inflammasome Responses to Hyphal Signals
Timothy M. Tucey,Jiyoti Verma-Gaur,Julie Nguyen,Victoria L. Hewitt,Tricia L. Lo,Miguel Shingu-Vazquez,Avril A. B. Robertson,James R. Hill,Filomena Pettolino,Travis Clarke Beddoe,Mark E. Cooper,Thomas Naderer,Ana Traven +12 more
- 25 May 2016
TL;DR: This study characterized the C. albicans endoplasmic reticulum (ER)-mitochondrion tether ERMES and shows that the ERM ES mmm1 mutant is severely crippled in killing macrophages despite hyphal formation and normal phagocytosis and survival, and establishes promising pathogen- and host-derived therapeutic strategies.
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