Timothy J. O’Donnell
University of Hawaii at Manoa
8 Papers
29 Citations
Timothy J. O’Donnell is an academic researcher from University of Hawaii at Manoa. The author has contributed to research in topics: Ligand & Nucleophilic substitution. The author has an hindex of 4, co-authored 8 publications.
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Papers
The Natural Products Atlas: An Open Access Knowledge Base for Microbial Natural Products Discovery.
Jeffrey A. van Santen,Gregoire Jacob,Amrit Leen Singh,Victor Aniebok,Marcy J. Balunas,Derek Bunsko,Fausto Carnevale Neto,Fausto Carnevale Neto,Fausto Carnevale Neto,Laia Castano-Espriu,Chen Chang,Trevor N. Clark,Jessica C. Little,David A. Delgadillo,Pieter C. Dorrestein,Katherine R. Duncan,Joseph M. Egan,Melissa M. Galey,F. P. Jake Haeckl,Alex Hua,Alison H. Hughes,Dasha Iskakova,Aswad S Khadilkar,Jung-Ho Lee,Sanghoon Lee,Nicole LeGrow,Dennis Y. Liu,Jocelyn Macho,Catherine McCaughey,Marnix H. Medema,Ram P. Neupane,Timothy J. O’Donnell,Jasmine S. Paula,Laura M. Sanchez,Anam F. Shaikh,Sylvia Soldatou,Barbara R. Terlouw,Tuan Anh Tran,Tuan Anh Tran,Mercia C. Valentine,Justin J. J. van der Hooft,Duy A. Vo,Mingxun Wang,Darryl Wilson,Katherine E. Zink,Roger G. Linington +45 more
TL;DR: The Natural Products Atlas is designed as a community-supported resource to provide a central repository for known natural product structures from microorganisms and is the first comprehensive, open access resource of this type.
Zinc limitation triggers anticipatory adaptations in Mycobacterium tuberculosis.
Allexa Dow,Preeti Sule,Timothy J. O’Donnell,Andrew Burger,Joshua T. Mattila,Brandi Antonio,Kevin Vergara,Endrei Marcantonio,L. Garry Adams,Nicholas G. James,Philip G. Williams,Jeffrey D. Cirillo,Sladjana Prisic +12 more
TL;DR: In this article, the authors proposed a model in which prolonged Zn2+ limitation defines a population of tuberculosis with anticipatory adaptations against impending immune attack, based on the evidence that Zn 2+-limited Mtb are more resistant to oxidative stress and exhibit increased survival and induce more severe pulmonary granulomas in mice.
Production and excretion of astaxanthin by engineered Yarrowia lipolytica using plant oil as both the carbon source and the biocompatible extractant
Ningyang Li,Zhenlin Han,Timothy J. O’Donnell,Ryan Kurasaki,Lexie Kajihara,Philip G. Williams,Yinjie J. Tang,Wei Wen Su +7 more
TL;DR: These findings facilitate industrial microbial biorefinery development that utilizes renewable lipids as feedstocks to not only produce high-value products but also effectively extract and recover the products, including non-native ones.
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Tolyporphins A–R, unusual tetrapyrrole macrocycles in a cyanobacterium from Micronesia, assessed quantitatively from the culture HT-58-2
Timothy J. O’Donnell,Joshua R. Gurr,Jingqiu Dai,Masahiko Taniguchi,Philip G. Williams,Jonathan S. Lindsey +5 more
TL;DR: Tolyporphins A–R are the newest additions to the family of native tetrapyrroles and LC-MS-dMRM and absorption spectroscopy have been employed for analysis of mixtures containing the 18 distinctive natural products.
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Tolyporphins L-R: Unusual Tetrapyrroles from a Brasilonema sp. of Cyanobacterium.
Joshua R. Gurr,Jingqiu Dai,Casey S. Philbin,Hope T. Sartain,Timothy J. O’Donnell,Wesley Y. Yoshida,Arnold L. Rheingold,Philip G. Williams +7 more
TL;DR: X-ray structures are reported for the first time for tolyporphin A, R, R (8), E (9), revealing unexpected stereochemical variation within the series.
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