Timothy Galitski

TL;DR: A high-throughput microfluidic imaging platform for single-cell studies of network response under hundreds of combined genetic perturbations and time-varying stimulant sequences and comprehensive analysis of 11 deletion mutants reveals both distinct thresholds for morphological switching and new dynamic phenotypes that are not observed in static conditions.

TL;DR: This work generalized the derivation of genetic-interaction networks from quantitative phenotype data and derived a network from agar-invasion phenotypes of mutant yeast that showed specific modes of genetic interaction with specific biological processes.

TL;DR: Integration of the quantitative proteomics with global protein interaction data using the Cytoscape platform led to the identification of several novel and liver-specific key regulatory components of the IFN response, which may be important in regulating the interplay between HCV, interferon and the host response to virus infection.

TL;DR: Evidence is provided for the role of androgenic hormones in coordinating the expression of critical components involved in distinct cellular processes and further establish a foundation for the comprehensive reconstruction of androgens-regulated protein networks and pathways in prostate cancer cells.