Timo Schinköthe
University of Cologne
55 Papers
548 Citations
Timo Schinköthe is an academic researcher from University of Cologne. The author has contributed to research in topics: Medicine & Internal medicine. The author has an hindex of 18, co-authored 33 publications. Previous affiliations of Timo Schinköthe include National University of Quilmes.
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Papers
Basic Fibroblast Growth Factor Controls Migration in Human Mesenchymal Stem Cells
Annette Schmidt,Dennis Ladage,Timo Schinköthe,Ursula Klausmann,Christoph Ulrichs,Franz-Josef Klinz,Klara Brixius,Stefan Arnhold,Biren Desai,Uwe Mehlhorn,Robert H. G. Schwinger,Peter Staib,Klaus Addicks,Wilhelm Bloch +13 more
TL;DR: ThebFGF gradient experiment showed that low concentrations of bFGF lead to an attraction of the cells, whereas higher concentrations resulted in repulsion, providing the possibility to a purposeful routing of MSCs.
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In vitro secreting profile of human mesenchymal stem cells.
TL;DR: The data indicated indicate that MSCs demonstrate all previously described functions in cellular interactions without an external stimulus, including angiogenic, immunosuppressive, anti-apoptotic, and proliferation-stimulating factors.
205
Ki-4(scFv)–ETA′, a new recombinant anti-CD30 immunotoxin with highly specific cytotoxic activity against disseminated Hodgkin tumors in SCID mice
Stefan Barth,Michael Huhn,B. Matthey,Samir Tawadros,Roland Schnell,Timo Schinköthe,Volker Diehl,Andreas Engert +7 more
TL;DR: A new recombinant immunotoxin (rIT) is constructed using the murine anti-CD30 hybridoma Ki-4 to construct a new rIT for possible clinical use in patients with CD30+ lymphoma and is a promising candidate for further clinical evaluation.
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Human bone marrow stroma cells display certain neural characteristics and integrate in the subventricular compartment after injection into the liquor system.
Stefan Arnhold,Helmut U. Klein,Franz-Josef Klinz,Yvonne Absenger,Annette Schmidt,Timo Schinköthe,Klara Brixius,Jolanta Kozlowski,Biren Desai,Wilhelm Bloch,Klaus Addicks +10 more
TL;DR: There was morphological as well as immunohistochemical evidence for a transdifferentiation within the host tissue and BMSCs could be efficiently transduced using a third-generation adenoviral vector, indicating their potential feasibility for a gene-therapeutic option.
82
•Journal Article
Human angiogenin fused to human CD30 ligand (Ang-CD30L) exhibits specific cytotoxicity against CD30-positive lymphoma.
Michael Huhn,Stephanie Sasse,Mehmet Kemal Tur,B. Matthey,Timo Schinköthe,Susanna M. Rybak,Stefan Barth,Andreas Engert +7 more
TL;DR: In this article, a new CD30 ligand-based fusion toxin (Ang-CD30L) using the human RNase angiogenin was developed for the treatment of CD30-positive malignancies.
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